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This study hypothesized that sustained sympathoexcitation via MMA slows down PHRR and that GSE supplementation is effective at improving PHRR in young individuals. 12 Participants were randomly assigned, via a double-blind, cross-over design, to either receive GSE (300mg, 2 capsules) or PL (300mg, 2 capsules), with a washout period of at least 72 hrs. between trials. A submaximal exercise test was performed using a cycle ergometer combined with isometric handgrip exercise using a handgrip dynamometer, and blood flow occlusion by placing a cuff over the brachial artery of the dominant arm. Post heart rate recovery (PHRR) was measured at 5 sec. intervals throughout the experiment. The PHRR was evaluated between GSE and PL at every min. for 300 sec.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experimental: Heart rate recovery with grape seed extract | Experimental | Grape seed extract: 300 mg, two capsules Starch: 300 mg, two capsules |
|
| Sham Comparator: Experimental: BFR exercise without histamine blockade | Placebo Comparator | Heart rate recovery with placebo (starch, 300 mg, 2 capsules) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 600 mg grape seed extract | Dietary Supplement | Each participant took either GSE (300 mg, 2 capsules) or a placebo (300 mg, 2 capsules filled with starch) 2 hours before their scheduled lab visit. The supplements were made to look identical to prevent any bias from the participants or the testers. There was a washout period of at least 72 hours, but no more than a week, between each trial. |
| Measure | Description | Time Frame |
|---|---|---|
| Heart rate recovery every minute and heart rate kinetics (tau) following exercise | 5 min after exercise |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| California Baptist University | Riverside | California | 92504 | United States |
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| ID | Term |
|---|---|
| D056604 | Grape Seed Extract |
| D013213 | Starch |
| ID | Term |
|---|---|
| D010936 | Plant Extracts |
| D028321 | Plant Preparations |
| D001688 | Biological Products |
| D045424 | Complex Mixtures |
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|
| 600 mg Starch | Dietary Supplement | Each participant took either GSE (300 mg, 2 capsules) or a placebo (300 mg, 2 capsules filled with starch) 2 hours before their scheduled lab visit. The supplements were made to look identical to prevent any bias from the participants or the testers. There was a washout period of at least 72 hours, but no more than a week, between each trial. |
|
| D004364 |
| Pharmaceutical Preparations |
| D005936 | Glucans |
| D001704 | Biopolymers |
| D011108 | Polymers |
| D046911 | Macromolecular Substances |
| D004040 | Dietary Carbohydrates |
| D002241 | Carbohydrates |
| D011134 | Polysaccharides |