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This study investigated if elevated BP and aortic stiffness characterized in obese individuals are attenuated following acute grape seed extract supplementation. It is hypothesized that acute dietary supplementation with grape seed extract attenuates aortic stiffness, systolic blood pressure, diastolic blood pressure, mean arterial pressure, and total peripheral resistance and these effects are partially due to reductions in peripheral vasoconstriction
Twenty men (obese = 10; normal body weight (NBW) = 10) participated in this study. Effects of placebo (PL: 600 mg) and GSE (600 mg) on systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), stroke volume (SV), cardiac output (Q), total peripheral resistance (TPR), and AoS were compared 2 h after ingestion of GSE or PL on different days, one week apart. Arterial blood pressure was measured using a sphygmomanometer from a brachial artery at the level of the heart on chair. HR and SV were continuously measured using a non-invasive device (Physio Flow). CO was calculated by HR X SV. TPR was calculated by MAP/CO.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| GSE group | Active Comparator | Subjects took a single dose of 600 mg GSE in capsule form through ingestion 2 hours prior to testing |
|
| Placebo group | Placebo Comparator | Subjects took a single dose of 600 mg starch in capsule form through ingestion 2 hours prior to testing |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Grape seed extract | Dietary Supplement | Two capsule grape seed extract (total 600 mg) |
|
| Measure | Description | Time Frame |
|---|---|---|
| change in heart rate | beats per minute | 2 hours after each supplementation |
| change in stroke volume | volume per stroke | 2 hours after each supplementation |
| change in cardiac output | total volume for a minute | 2 hours after each supplementation |
| change in systolic blood pressure | pressure exerted during contraction | 2 hours after each supplementation |
| change in diastolic blood pressure | pressure exerted during relaxation | 2 hours after each supplementation |
| change in mean arterial pressure | One reported pressure (systolic blood pressure-diastolic blood pressure)/3 + diastolic blood pressure | 2 hours after each supplementation |
| change in total peripheral resistance | One reported value (mean arterial pressure/cardiac output) | 2 hours after each supplementation |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| California Baptist University | Riverside | California | 92504 | United States |
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Double blind, cross-over design
| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D056604 | Grape Seed Extract |
| ID | Term |
|---|---|
| D010936 | Plant Extracts |
| D028321 | Plant Preparations |
| D001688 | Biological Products |
| D045424 | Complex Mixtures |
| D004364 | Pharmaceutical Preparations |
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