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This study was to examine the additive benefits with combined grape seed extract (GSE) and L-citrulline supplementation on hemodynamic responses to dynamic exercise, 11 young, healthy males were recruited for this study.
The investigators aimed the additive effects of combined grape seed extract (GSE) and L-citrulline supplementation on hemodynamic responses to dynamic exercise, 11 young, healthy males were recruited for this study. Effects of 7 days of combined GSE with L-citrulline supplementation on systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial blood pressure (MAP), cardiac output (CO), total vascular conductance (TVC), and oxygen consumption (O2) were examined at rest and during cycling exercise.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Randomized double blind grape seed extract design | Active Comparator | Grape see extract |
|
| Randomized double blind placebo design | Placebo Comparator | Placebo |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Grape seed extract | Dietary Supplement | Effects of 7 days of combined GSE with L-citrulline supplementation on hemodynamic responses at rest and during cycling exercise. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Systolic blood pressure (mmHg) | by sphygmomanometer | 7 days |
| Diastolic blood pressure (mmHg) | by sphygmomanometer | 7 days |
| Mean arterial pressure (mmHg) | calculated (MAP = (SBP-DBP)/3 + DBP | 7 days |
| Heart rate (bpm) | measured using Physio Flow (non-invasive device) | 7 days |
| Stroke volume (ml) | measured using Physio Flow (non-invasive device) | 7 days |
| Cardiac output (l/min) | calculated: HR (bpm) x SV (ml) | 7 days |
| Total vascular conductance (ml/min/mmHg) | calculated: CO (ml/min) / MAP (mmHg) | 7 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jong-Kyung Kim, Ph.D | California Baptist University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| California Baptist University | Riverside | California | 92504 | United States |
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| ID | Term |
|---|---|
| D056604 | Grape Seed Extract |
| ID | Term |
|---|---|
| D010936 | Plant Extracts |
| D028321 | Plant Preparations |
| D001688 | Biological Products |
| D045424 | Complex Mixtures |
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| Placebo | Dietary Supplement | Effects of 7 days of placebo supplementation on hemodynamic responses at rest and during cycling exercise. |
|
| D004364 |
| Pharmaceutical Preparations |