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The aim of this study was to determine whether grape seed extract (GSE) supplementation could reduce the blood pressure (BP) in response to static exercise and post exercise muscular ischemia (PEMI) in normotensive young adults. In 12 healthy subjects (7 male and 5 female, 24.6±3.4 yr), we compared acute effect of both GSE (600 mg) and placebo (PL: 600 mg) on changes from rest in systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), heart rate (HR), stroke volume (SV), cardiac output (CO), and total peripheral resistance (TPR) during static exercise (SE) and PEMI. Subjects completed 2 min of SE at 30% of maximal voluntary contraction (MVC) followed by 2 min of PEMI.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Randomized double blind grape seed extract design | Active Comparator | Grape seed extract |
|
| Control | Placebo Comparator | Placebo (starch) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Grape seed extract | Dietary Supplement | Acute effect of dietary supplementation with GSE on hemodynamic responses during static exercise and muscle metaboreflex and during cycling exercise. |
| Measure | Description | Time Frame |
|---|---|---|
| Systolic blood pressure (mmHg) by sphygmomanometer | Measured from the brachial artery | 24 hours |
| Diastolic blood pressure (mmHg) by sphygmomanometer | Measured from the brachial artery | 24 hours |
| Mean arterial pressure (mmHg) | calculated (MAP = (SBP-DBP)/3 + DBP | 24 hours |
| Heart rate (bpm) | measured using Physio Flow (non-invasive device) | 24 hours |
| Stroke volume (ml) | measured using Physio Flow (non-invasive device) | 24 hours |
| Cardiac output (l/min) | calculated: HR (bpm) x SV (ml) | 24 hours |
| Total peripheral resistance (mmHg/l/min) | calculated: MAP (mmHg) / CO (l/min) | 24 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jong-Kyung Kim | California Baptist University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| California Baptist University | Riverside | California | 92504 | United States |
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| ID | Term |
|---|---|
| D056604 | Grape Seed Extract |
| ID | Term |
|---|---|
| D010936 | Plant Extracts |
| D028321 | Plant Preparations |
| D001688 | Biological Products |
| D045424 | Complex Mixtures |
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| D004364 |
| Pharmaceutical Preparations |