Effects of Acute Grape Seed Extract Supplementation on Muscle Metaboreflex in Healthy Young Individuals

Effects of Acute Grape Seed Extract Supplementation on Muscle Metaboreflex in Healthy

The aim of this study was to determine whether grape seed extract (GSE) supplementation could reduce the blood pressure (BP) in response to static exercise and post exercise muscular ischemia (PEMI) in normotensive young adults. In 12 healthy subjects (7 male and 5 female, 24.6±3.4 yr), we compared acute effect of both GSE (600 mg) and placebo (PL: 600 mg) on changes from rest in systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), heart rate (HR), stroke volume (SV), cardiac output (CO), and total peripheral resistance (TPR) during static exercise (SE) and PEMI. Subjects completed 2 min of SE at 30% of maximal voluntary contraction (MVC) followed by 2 min of PEMI.

Inclusion Criteria:

• Healthy volunteers (SBP < 120 mmHg, DBP < 80 mmHg)

Exclusion Criteria:

• cardiovascular and/or pulmonary disease,
• musculoskeletal disorders
• medications that prevent the safe completion of the exercise protocol