To assess Avance QQ Collagen product on skin condition improvement

Inclusion Criteria:

• Healthy male or female adults, age above 18 years old;
• The grade of crow's feet above 2 (Han et al. Sci Rep 13, 18903 (2023));
• Commitment not to use products having activity comparable with that of the product to be tested during the study period;
• Free of any dermatological or systemic disorder that would interfere with results.

Exclusion Criteria:

• Subject with obvious skin surface damage;
• Subject who had oral or topical medication which may affect skin condition within 1 month;
• Subject who is a vegetarian or likely to be acutely allergic to the listed ingredients in the product;
• Female who is pregnant, nursing or planning to become pregnant during the course of the study;
• Received facial laser therapy, chemical peeling in the past 2 months.