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To assess collagen and zhuyin drink on skin & body condition improvement
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo drink | Placebo Comparator |
| |
| Collagen and Zhuyin Drinks | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Placebo drink | Dietary Supplement | consume 1 bottle (50 mL) per day for 28 days |
| |
| Measure | Description | Time Frame |
|---|---|---|
| The change of skin moisture | Corneometer® CM825 was utilized to measure skin moisture. Units: arbitrary Corneometer® units 0-120 | Change from Baseline skin moisture at 4 weeks |
| The change of skin wrinkles | VISIA Complexion Analysis System was utilized to measure wrinkles. Units: arbitrary units | Change from Baseline skin wrinkles at 4 weeks |
| The change of skin collagen density | DermaLab® USB - 20 MHz High Freq. Ultrasound probe was utilized to scan and analyze skin collagen density. Units:Intensity score | Change from Baseline skin collagen density at 4 weeks |
| The change of TEWL | Tewameter® TM 300 was utilized to measure TEWL. Units: g/h/m2 | Change from Baseline TEWL at 4 weeks |
| The change of skin brightness | Glossymeter GL 200 was utilized to measure skin brightness. Units: arbitrary units | Change from Baseline skin brightness at 4 weeks |
| The change of interleukin-6 | Venous blood was sampled to measure concentrations of interleukin-6. | Change from Baseline skin brightness at 4 weeks |
| The change of interleukin-8 | Venous blood was sampled to measure concentrations of interleukin-8. | Change from Baseline skin brightness at 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| The change of skin texture | VISIA Complexion Analysis System was utilized to measure skin texture. Units: arbitrary units | Change from Baseline skin texture at 4 weeks |
| The change of skin pores |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chia Nan University of Pharmacy ＆ Science | Tainan | 71710 | Taiwan |
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| ID | Term |
|---|---|
| D012871 | Skin Diseases |
| ID | Term |
|---|---|
| D017437 | Skin and Connective Tissue Diseases |
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Single
| Collagen Cubilose Drink |
| Dietary Supplement |
consume 1 bottle (50 mL) per day for 28 days |
|
| The change of Tumor necrosis factor | Venous blood was sampled to measure concentrations of Tumor necrosis factor. | Change from Baseline skin brightness at 4 weeks |
| The change of Matrix metalloproteinase-1 | Venous blood was sampled to measure concentrations of Matrix metalloproteinase-1 . | Change from Baseline skin brightness at 4 weeks |
| The change of metallopeptidase inhibitor 1 | Venous blood was sampled to measure concentrations of metallopeptidase inhibitor 1. | Change from Baseline skin brightness at 4 weeks |
VISIA Complexion Analysis System was utilized to measure skin pores. Units: arbitrary units
| Change from Baseline skin pores at 4 weeks |
| The change of skin spots | VISIA Complexion Analysis System was utilized to measure skin spots. Units: arbitrary units | Change from Baseline skin spots at 4 weeks |
| The change of red areas | VISIA Complexion Analysis System was utilized to measure red areas. Units: arbitrary units | Change from Baseline red areas at 4 weeks |