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To assess Collagen Drink on skin condition and sleep quality improvement
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo drink | Placebo Comparator |
| |
| Collagen drink | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Placebo drink | Dietary Supplement | Blank |
| |
| Collagen Juice Drink |
| Measure | Description | Time Frame |
|---|---|---|
| The change of skin wrinkles | VISIA Complexion Analysis System was utilized to measure skin wrinkles. Units: arbitrary units | Change from Baseline skin wrinkles at 8 weeks |
| The change of skin texture | VISIA Complexion Analysis System was utilized to measure skin texture. Units: arbitrary units | Change from Baseline skin texture at 8 weeks |
| The change of skin collagen density | DermaLab® Series SkinLab Combo was utilized to measure skin pores. Units: arbitrary units | Change from Baseline skin collagen density at 8 weeks |
| The change of skin elasticity | Cutometer® MPA580 was utilized to measure skin elasticity. Units: arbitrary units | Change from Baseline skin elasticity at 8 weeks |
| The change of skin L* value | Chroma Meter MM500 was utilized to measure skin L* value. Units: arbitrary units, 0-100 | Change from Baseline L* value at 8 weeks |
| The change of sleep quality | Self-assessment questionnaire was utilized to survey sleep quality. | Change from Baseline sleep quality at 8 weeks |
| The change of AGEs of blood | Venous blood was sampled to measure AGEs | Change from Baseline AGEs at 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| The change of skin melanin index | Soft Plus was utilized to measure skin melanin index. Units: arbitrary units | Change from Baseline skin melanin index at 8 weeks |
| The change of skin pores | VISIA Complexion Analysis System was utilized to measure skin pores. Units: arbitrary units |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chia Nan University of Pharmacy ＆ Science | Tainan | 71710 | Taiwan |
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| ID | Term |
|---|---|
| D012871 | Skin Diseases |
| D020447 | Parasomnias |
| ID | Term |
|---|---|
| D017437 | Skin and Connective Tissue Diseases |
| D012893 | Sleep Wake Disorders |
| D009422 | Nervous System Diseases |
| D001523 | Mental Disorders |
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| Dietary Supplement |
Testing product |
|
|
| The change of TIMP-1 of blood | Venous blood was sampled to measure TIMP-1 | Change from Baseline TIMP-1 at 8 weeks |
| The change of desmosine of blood | Venous blood was sampled to measure desmosine | Change from Baseline desmosine at 8 weeks |
| Change from Baseline skin pores at 8 weeks |
| The change of skin a* value | Chroma Meter MM500 was utilized to measure skin a* value. Units: arbitrary units | Change from Baseline skin a* value at 8 weeks |
| The change of skin hydration | Corneometer® CM825 was utilized to measure skin hydration. Units: arbitrary Corneometer® units 0-120 | Change from Baseline skin hydration at 8 weeks |
| The change of transepidermal water loss | Tewameter® TM300 was utilized to measure skin hydration. Units: g/hm² | Change from Baseline transepidermal water loss at 8 weeks |