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To assess Collagen Peptide Drink on skin condition improvement
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo drink | Placebo Comparator |
| |
| Collagen Peptide Drink | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Collagen Peptide Drink | Dietary Supplement | Testing product |
|
| Measure | Description | Time Frame |
|---|---|---|
| The change of skin wrinkles | VISIA Complexion Analysis System was utilized to measure skin wrinkles. Units: arbitrary units | Change from Baseline skin wrinkles at 4 weeks |
| The change of skin texture | VISIA Complexion Analysis System was utilized to measure skin texture. Units: arbitrary units | Change from Baseline skin texture at 4 weeks |
| The change of skin collagen density | DermaLab® Series SkinLab Combo was utilized to measure skin pores. Units: arbitrary units | Change from Baseline skin collagen density at 4 weeks |
| The change of skin elasticity | Soft Plus was utilized to measure skin elasticity. Units: arbitrary units | Change from Baseline skin elasticity at 4 weeks |
| The change of MMP-1 of blood | Venous blood was sampled to measure MMP-1 | Change from Baseline MMP-1 at 4 weeks |
| The change of TIMP-1 of blood | Venous blood was sampled to measure TIMP-1 | Change from Baseline TIMP-1 at 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| The change of skin melanin index | Soft Plus was utilized to measure skin melanin index. Units: arbitrary units | Change from Baseline skin melanin index at 4 weeks |
| The change of skin L* value | Chroma Meter MM500 was utilized to measure skin L* value. Units: arbitrary units, 0-100 |
| Measure | Description | Time Frame |
|---|---|---|
| The change of total cholesterol of blood | Venous blood was sampled to measure total cholesterol | Change from Baseline total cholesterol at 4 weeks |
| The change of triglyceride of blood | Venous blood was sampled to measure triglyceride |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Chia-Hua Liang | Chia Nan University of Pharmacy ＆ Science | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chia Nan University of Pharmacy ＆ Science | Tainan | 71710 | Taiwan |
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| ID | Term |
|---|---|
| D012871 | Skin Diseases |
| ID | Term |
|---|---|
| D017437 | Skin and Connective Tissue Diseases |
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| Placebo drink | Dietary Supplement | Blank |
|
| Change from Baseline L* value at 4 weeks |
| The change of skin spots | VISIA Complexion Analysis System was utilized to measure skin spots. Units: arbitrary units | Change from Baseline skin spots at 4 weeks |
| The change of skin UV spots | VISIA Complexion Analysis System was utilized to measure skin UV spots. Units: arbitrary units | Change from Baseline skin UV spots at 4 weeks |
| The change of skin brown spots | VISIA Complexion Analysis System was utilized to measure skin brown spots. Units: arbitrary units | Change from Baseline skin brown spots at 4 weeks |
| The change of TNF-α of blood | Venous blood was sampled to measure TNF-α | Change from Baseline TNF-α at 4 weeks |
| The change of IL-10 of blood | Venous blood was sampled to measure IL-10 | Change from Baseline IL-10 at 4 weeks |
| The change of SOD-RBC of blood | Venous blood was sampled to measure SOD-RBC | Change from Baseline SOD-RBC at 4 weeks |
| The change of f-thiols of blood | Venous blood was sampled to measure f-thiols | Change from Baseline f-thiols at 4 weeks |
| The change of t-GSH of blood | Venous blood was sampled to measure t-GSH | Change from Baseline t-GSH at 4 weeks |
| The change of GST-RBC of blood | Venous blood was sampled to measure GST-RBC | Change from Baseline GST-RBC at 4 weeks |
| The change of MDA of blood | Venous blood was sampled to measure MDA | Change from Baseline MDA at 4 weeks |
| The change of skin moisture | Corneometer® CM825 was utilized to measure skin moisture. Units: arbitrary Corneometer® units 0-120 | Change from Baseline skin moisture at 4 weeks |
| The change of blood total antioxidant capacity (TAC) | Venous blood was sampled to measure concentrations of TAC | Change from Baseline TAC at 4 weeks |
| Change from Baseline triglyceride at 4 weeks |
| The change of SGOT of blood | Venous blood was sampled to measure SGOT | Change from Baseline SGOT at 4 weeks |
| The change of SGPT of blood | Venous blood was sampled to measure SGPT | Change from Baseline SGPT at 4 weeks |
| The change of BUN of blood | Venous blood was sampled to measure BUN | Change from Baseline BUN at 4 weeks |
| The change of creatinine of blood | Venous blood was sampled to measure creatinine | Change from Baseline creatinine at 4 weeks |
| The change of uric acid of blood | Venous blood was sampled to measure uric acid | Change from Baseline uric acid at 4 weeks |