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To assess if oral intake of collagen peptide can improve skin conditions such as skin thickness, density and firmness.
This is an one site, randomized, double-blind controlled clinical trial to assess the oral supplement of LISAVEI collagen peptide solid beverage on skin ageing improvement. Study product with collagen peptide and placebo product without collagen were randomly assigned to 90 eligible participants enrolled according to the inclusion and exclusion criteria. They took the assigned product once daily dissolved in 100 ml warm water for 12 weeks with 4-week regression phase(without intake of the test products), and visit the study site in Shanghai for four times(before starting the treatment, after 8 and 12 weeks, and 4 weeks after the last intake). Skin measurements including skin firmness, skin density, skin hydration and skin barrier were carried out at each visit with professional equipment and imaging system. Data were analyzed to validate if the administration of the test collagen peptide solid beverage will improve skin aging parameters such as firmness, thickness, density, hydration and skin barrier compared to placebo. The lasting effect was also observed by comparing between the two groups after 4-week regression time.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Active Comparator | Active Comparator | collagen peptide solid beverage |
|
| Placebo Comaprator | Placebo Comparator | placebo solid beverage |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Active Comparator | Dietary Supplement | LISAVEI collagen peptide solid beverage ( contain 5 g collagen peptide),once daily for 12 weeks |
|
| Measure | Description | Time Frame |
|---|---|---|
| Skin firmness | The changes of skin firmness parameter tested by Cutometer MPA580 | before product treatment (T 0), after 8 weeks(T 1)and 12 weeks(T 2) of daily product intake, 4 weeks after the last intake(T 3, 4-week regression phase) |
| Skin thickness | The changes of skin thickness (μm) tested by Ultrascan UC 22 | before product treatment (T 0), after 8 weeks(T 1)and 12 weeks(T 2) of daily product intake, 4 weeks after the last intake(T 3, 4-week regression phase) |
| Skin density | The changes of skin density tested by Ultrascan UC 22 | before product treatment (T 0), after 8 weeks(T 1)and 12 weeks(T 2) of daily product intake, 4 weeks after the last intake(T 3, 4-week regression phase) |
| Measure | Description | Time Frame |
|---|---|---|
| Skin hydration | The changes of skin hydration tested by Corneometer CM825 | before product treatment (T 0), after 8 weeks(T 1)and 12 weeks(T 2) of daily product intake, 4 weeks after the last intake(T 3, 4-week regression phase) |
| Skin barrier |
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Inclusion Criteria:
5. Agree to refrain from wearing make-up on the face on the each study visit
Exclusion Criteria
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shanghai Fumei Dermatology Clinic | Shanghai | Shanghai Municipality | 021 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41311286 | Derived | Wang Y, Zhu W, Luo W, Ma Y, Zhou Y. The Sustained Effects of Bioactive Collagen Peptides on Skin Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study. J Cosmet Dermatol. 2025 Dec;24(12):e70565. doi: 10.1111/jocd.70565. |
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| Placebo Comparator | Dietary Supplement | placebo solid beverage (Maltodextrin with edible flavor),once daily for 12 weeks |
|
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The changes of Trans Epidermal Water Loss (skin barrier parameter) tested by Tewameter TM300
| before product treatment (T 0), after 8 weeks(T 1)and 12 weeks(T 2) of daily product intake, 4 weeks after the last intake(T 3, 4-week regression phase) |
| Facial image | Photo documents of left, right and frontal facial views | before product treatment (T 0), after 8 weeks(T 1)and 12 weeks(T 2) of daily product intake, 4 weeks after the last intake(T 3, 4-week regression phase) |