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This study will determine the effect of 6 months of supplementation with krill oil on muscle strength and mass in middle-aged adults. The study hypothesis is that krill oil supplementation will increase muscle strength and mass in middle-aged adults.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention | Experimental | Krill oil 4g/day for 24 weeks |
|
| Placebo | Placebo Comparator | Vegetable oil 4g/day for 24 weeks |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Krill oil | Dietary Supplement | Superba krill oil |
| |
| Vegetable oil |
| Measure | Description | Time Frame |
|---|---|---|
| Change in knee extensor maximal isometric torque ( MVC) | Knee extensor maximal isometric torque measured during a maximal voluntary contraction | Change from baseline to 24 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change in fat mass | Whole body fat mass measured by measured via bio-electrical impedance | Change from baseline to 24 weeks |
| Change in lean mass | Whole body lean mass measured by measured via bio-electrical impedance |
| Measure | Description | Time Frame |
|---|---|---|
| Change in systemic inflammation | Plasma levels of C-reactive protein, IL-1, IL-6, IL-8, IL-10, and TNF-α | Change from baseline to 24 weeks |
| Change in muscle inflammation | Muscle total protein levels of TNF-α, IL-1β, IL-6, IL-8, MCP-1 and total and phosphorylated levels of NFκB, JNK1/2 and STAT3 |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Glasgow | Glasgow | United Kingdom |
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| ID | Term |
|---|---|
| D055948 | Sarcopenia |
| ID | Term |
|---|---|
| D009133 | Muscular Atrophy |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D010938 | Plant Oils |
| ID | Term |
|---|---|
| D009821 | Oils |
| D008055 | Lipids |
| D028321 | Plant Preparations |
| D001688 | Biological Products |
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1:1 basis
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Supplements will be identical in look and taste
| Dietary Supplement |
Mixed vegetable oil |
|
| Change from baseline to 24 weeks |
| Change in omega-3 levels | Red blood cell omega-3 levels | Change from baseline to 24 weeks |
| Change in Grip strength | Grip strength measured with a hand held dynamometer | Change from baseline to 24 weeks |
| Change in Muscle thickness | Vastus lateralis muscle thickness measured by ultrasound | Change from baseline to 24 weeks |
| Change from baseline to 24 weeks |
| Change in muscle anabolic signalling | Muscle total and phosphorylated protein levels of mTOR, IRS-1, Akt, 4EBP-1, p70S6K, RPS6, FOXO-1, GSK3β and total protein levels of MAFBx and MURF-1 | Change from baseline to 24 weeks |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |
| D045424 |
| Complex Mixtures |