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The aim of the study is to compare the effects of Krill Oil and Fish Oil supplementation on muscle function in older adults. The secondary aim is to investigate the mechanisms underlying the beneficial effects previously observed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Fish oil | Active Comparator | Fish oil 4 g/day |
|
| Krill oil | Active Comparator | Krill oil 4g/day |
|
| Placebo | Placebo Comparator | Vegetable oil 4g/day |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Fish oil | Dietary Supplement | EPA rich fish oil |
| |
| Kril oil |
| Measure | Description | Time Frame |
|---|---|---|
| Change in knee extensor maximal isometric torque ( MVC) | Knee extensor maximal isometric torque measured during a maximal voluntary contraction | Change from baseline to 16 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change in fat mass | Whole body fat mass measured by measured via bio-electrical impedance | Change from baseline to 16 weeks |
| Change in lean mass | Whole body lean mass measured by measured via bio-electrical impedance |
| Measure | Description | Time Frame |
|---|---|---|
| Step Time (Sec) | Measured during a 4m walk using a gaitrite mat | Change from baseline to 16 weeks |
| Cycle Time (Sec) | Measured during a 4m walk using a gaitrite mat |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Stuart Robert Gray | Glasgow | Scotland | United Kingdom |
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| ID | Term |
|---|---|
| D055948 | Sarcopenia |
| ID | Term |
|---|---|
| D009133 | Muscular Atrophy |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D005395 | Fish Oils |
| D010938 | Plant Oils |
| ID | Term |
|---|---|
| D009821 | Oils |
| D008055 | Lipids |
| D028321 | Plant Preparations |
| D001688 | Biological Products |
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1:1:1 basis
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Supplements will be identical in look and taste
| Dietary Supplement |
Superba Krill Oil |
|
| Vegetable oil | Dietary Supplement | Mixed vegetable oil |
|
| Change from baseline to 16 weeks |
| Blood sample | Red Blood Cell Omega-3 levels | Change from baseline to 16 weeks |
| Change in Grip strength | Grip strength measured with a hand held dynamometer | Change from baseline to 16 weeks |
| Change in Muscle thickness | Vastus lateralis muscle thickness measured by ultrasound | Change from baseline to 16 weeks |
| Force steadiness during submaximal isometric knee extensor contractions | Measured by using intramuscular iEMG | Change from baseline to 16 weeks |
| Neuromuscular Junction (NMJ) | Measured by iEMG | Change from baseline to 16 weeks |
| Change in gait speed | Time taken to walk 4 metres at a normal walking pace | Change from baseline to 16 weeks |
| Change in Chair rise time | A 30-second sit-to-stand test measured functional abilities | Change from baseline to 16 weeks |
| Change from baseline to 16 weeks |
| Step Length (CM) | Measured during a 4m walk using a gaitrite mat | Change from baseline to 16 weeks |
| Stride Length (CM) | Measured during a 4m walk using a gaitrite mat | Change from baseline to 16 weeks |
| H-H Base Support (CM) | Measured during a 4m walk using a gaitrite mat | Change from baseline to 16 weeks |
| Single Support (%GC) | Measured during a 4m walk using a gaitrite mat | Change from baseline to 16 weeks |
| Double Support (%GC) | Measured during a 4m walk using a gaitrite mat | Change from baseline to 16 weeks |
| Swing (%GC) | Measured during a 4m walk using a gaitrite mat | Change from baseline to 16 weeks |
| Stance (%GC) | Measured during a 4m walk using a gaitrite mat | Change from baseline to 16 weeks |
| Step/ Extremity Ratio | Measured during a 4m walk using a gaitrite mat | Change from baseline to 16 weeks |
| Toe In/ Out (deg) | Measured during a 4m walk using a gaitrite mat | Change from baseline to 16 weeks |
| Distance (CM) | Measured during a 4m walk using a gaitrite mat | Change from baseline to 16 weeks |
| Ambulation Time (Sec) | Measured during a 4m walk using a gaitrite mat | Change from baseline to 16 weeks |
| Velocity (CM/Sec) | Measured during a 4m walk using a gaitrite mat | Change from baseline to 16 weeks |
| Mean Normalized Velocity | Measured during a 4m walk using a gaitrite mat | Change from baseline to 16 weeks |
| Number of Steps | Measured during a 4m walk using a gaitrite mat | Change from baseline to 16 weeks |
| Cadence (Steps/Min) | Measured during a 4m walk using a gaitrite mat | Change from baseline to 16 weeks |
| Step Time Differential (Sec) | Measured during a 4m walk using a gaitrite mat | Change from baseline to 16 weeks |
| Step Length Differential (CM) | Measured during a 4m walk using a gaitrite mat | Change from baseline to 16 weeks |
| Cycle Time Differential (Sec) | Measured during a 4m walk using a gaitrite mat | Change from baseline to 16 weeks |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |
| D045424 |
| Complex Mixtures |