Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The aim of this study is to determine whether krill oil supplementation enhances effects of a pragmatic resistance exercise programme on adaptations in muscle strength, mass, function and neuromuscular function in sedentary older adults. Hypothesis - krill oil supplementation will enhance the beneficial effects of resistance exercise on muscle strength, function, mass and neuromuscular function in sedentary older adults.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Vegetable oil + Resistance exercise | Placebo Comparator | 4g/day vegetable oil and home based resistance exercise for 16 weeks |
|
| Krill oil + Resistance exercise | Active Comparator | 4g/day krill oil and home based resistance exercise for 16 weeks |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Vegetable oil | Dietary Supplement | Mixed vegetable oil |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Nueromuscular Junction (NMJ) transmission instability | NMJ transmission instability will be measured by iEMG | Change from baseline to 16 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Knee extensor maximal torque | Knee extensor maximal torque will be measured by a load cell | Change from baseline to 8 16 weeks |
| 30s chair stand test | measuring the functional abilities |
| Measure | Description | Time Frame |
|---|---|---|
| Step Time (sec) | Measured during a 4m walk using a gaitrite mat | Change from baseline to 16 weeks |
| Cycle Time (sec) | Measured during a 4m walk using a gaitrite mat |
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Glasgow | Glasgow | United Kingdom |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D055948 | Sarcopenia |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D009133 | Muscular Atrophy |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D010938 | Plant Oils |
| ID | Term |
|---|---|
| D009821 | Oils |
| D008055 | Lipids |
| D028321 | Plant Preparations |
| D001688 | Biological Products |
Not provided
Not provided
1:1 parallel group design
Not provided
Not provided
All supplements will be matched for taste and look
| Krill oil |
| Dietary Supplement |
Superba Krill Oil |
|
| Home-based resistance exercise | Other | Home based resistance band and body weight exercise |
|
| Change from baseline to 16 weeks |
| Gait speed | measuring the functional abilities | Change from baseline to 16 weeks |
| Force steadiness during submaximal isometric knee extensor contractions | Steadiness of force whilst contracting | Change from baseline to 16 weeks |
| Red Blood Cell Omega-3 levels | Change from baseline to 16 weeks |
| Grip strength | Grip strength will be measured by handgrip dynamometer | Change from baseline to 16 weeks |
| Muscle thickness | Vastus Lateralis muscle thickness will be measured by ultrasound | Change from baseline to 16 weeks |
| Change from baseline to 16 weeks |
| Step Length (cm) | Measured during a 4m walk using a gaitrite mat | Change from baseline to16 weeks |
| Stride Length (cm) | Measured during a 4m walk using a gaitrite mat | Change from baseline to16 weeks |
| H-H Base Support (cm) | Measured during a 4m walk using a gaitrite mat | Change from baseline to 16 weeks |
| Single Support (%GC) | Measured during a 4m walk using a gaitrite mat | Change from baseline to 16 weeks |
| Double Support (%GC) | Measured during a 4m walk using a gaitrite mat | Change from baseline to 16 weeks |
| Swing (%GC) | Measured during a 4m walk using a gaitrite mat | Change from baseline to 16 weeks |
| Stance (%GC) | Measured during a 4m walk using a gaitrite mat | Change from baseline to 16 weeks |
| Step/ Extremity Ratio | Measured during a 4m walk using a gaitrite mat | Change from baseline to 16 weeks |
| Toe In / Out (deg) | Measured during a 4m walk using a gaitrite mat | Change from baseline to 16 weeks |
| Distance (cm) | Measured during a 4m walk using a gaitrite mat | Change from baseline to 16 weeks |
| Ambulation Time (sec) | Change from baseline to 16 weeks |
| Velocity (cm/sec) | Measured during a 4m walk using a gaitrite mat | Change from baseline to 16 weeks |
| Mean Normalized Velocity | Measured during a 4m walk using a gaitrite mat | Change from baseline to16 weeks |
| Number of Steps | Measured during a 4m walk using a gaitrite mat | Change from baseline to 16 weeks |
| Cadence (Steps/Min) | Measured during a 4m walk using a gaitrite mat | Change from baseline to 16 weeks |
| Step Time Differential (sec) | Measured during a 4m walk using a gaitrite mat | Change from baseline to 16 weeks |
| Step Length Differential (cm) | Measured during a 4m walk using a gaitrite mat | Change from baseline to 16 weeks |
| Cycle Time Differential (sec) | Measured during a 4m walk using a gaitrite mat | Change from baseline to 16 weeks |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |
| D001519 | Behavior |
| D045424 |
| Complex Mixtures |