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The aim of this study is to determine the effects of krill oil supplementation on muscle mass in function in older adults. Half of the participants will receive krill oil supplements and the other half a placebo.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Placebo Comparator | 4g/day of mixed vegetable oil supplements |
|
| Krill | Experimental | 4g/day krill oil |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Krill Oil | Dietary Supplement | Aker Biomarine Superba Krill Oil |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Muscle strength | knee extensor muscle strength | Change from baseline to 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Grip strength | Grip strength | Change from baseline to 6 months |
| Change in Muscle thickness | Vastus lateralis muscle thickness |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Stuart Gray, PhD | University of Glasgow | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Stuart Robert Gray | Glasgow | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41344001 | Derived | Hayman O, Alkhedhairi SA, Combet E, Quinn TJ, Hunter AM, Goodall S, Gray SR. Do the effects of krill oil supplementation on skeletal muscle function and size in older adults differ by sex, age or BMI: A secondary analysis of a randomised controlled trial. J Nutr Health Aging. 2026 Jan;30(1):100747. doi: 10.1016/j.jnha.2025.100747. Epub 2025 Dec 3. | |
| 35504165 |
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| ID | Term |
|---|---|
| D055948 | Sarcopenia |
| ID | Term |
|---|---|
| D009133 | Muscular Atrophy |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| Placebo |
| Dietary Supplement |
Mixed vegetable oil |
|
| Change from baseline to 6 months |
| Change in Short performance physical battery test | SPPB | Change from baseline to 6 months |
| Change in Body Fat | Measured by BIA | Change from baseline to 6 months |
| Change in Lean Mass | Measured by BIA | Change from baseline to 6 months |
| Change in Fasting glucose | Fasting glucose | Change from baseline to 6 months |
| Change in Blood lipids | Blood lipids | Change from baseline to 6 months |
| Change in CRP | CRP | Change from baseline to 6 months |
| Change in Erythrocyte fatty acid profile | Erythrocyte fatty acid profile | Change from baseline to 6 months |
| Alkhedhairi SA, Aba Alkhayl FF, Ismail AD, Rozendaal A, German M, MacLean B, Johnston L, Miller AA, Hunter AM, Macgregor LJ, Combet E, Quinn TJ, Gray SR. The effect of krill oil supplementation on skeletal muscle function and size in older adults: A randomised controlled trial. Clin Nutr. 2022 Jun;41(6):1228-1235. doi: 10.1016/j.clnu.2022.04.007. Epub 2022 Apr 20. |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |