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This study will recruit 30 adults (men and women, aged 18 years and over) who will be randomly assigned to one of two groups in a 12-week double-blind pilot trial. Participants will receive either:
Participants will be instructed to maintain their usual diet and physical activity patterns throughout the study.
Eligibility will be assessed using a health screening questionnaire, completed with the researcher's assistance, before obtaining informed consent. Habitual physical activity will be evaluated using the International Physical Activity Questionnaire (short form), and dietary intake will be assessed with the EPIC Food Frequency Questionnaire (FFQ) at both the beginning and end of the study. In addition, participants will record their fish consumption weekly using a dedicated logbook.
Measurements will be taken at baseline and after 12 weeks, including:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Arm 1: Krill Oil group | Experimental | 4 g/day of krill oil (Superba™ Antarctic Krill Oil, 1000 mg capsules) for 12 weeks. |
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| Arm 2: Control group | Placebo Comparator | 4 g/day of placebo (vegetable oil capsules) for 12 weeks. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Krill oil supplementation | Dietary Supplement | Krill oil supplementation program providing 4 g/day of krill oil (Superba™ Antarctic Krill Oil, 1000 mg capsules) for 12 weeks. |
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| Measure | Description | Time Frame |
|---|---|---|
| Grip strength | Measured using a handgrip dynamometer | Changes from baseline to week 12 |
| Measure | Description | Time Frame |
|---|---|---|
| Knee extendor Strength | Knee extensor maximal torque measured during an isometric maximal voluntary contraction (MVC) | Changes from baseline to week 12 |
| Muscle size, assessed as vastus lateralis muscle thickness by ultrasound |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Professor Stuart Gray | Contact | +441413302569 | stuart.gray@glasgow.ac.uk |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Lab 242, Sir James Black Building, University of Glasgow | Recruiting | Glasgow | Lanarkshire | G12 8TA | United Kingdom |
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| Control | Dietary Supplement | Vegetable oil supplementation (4 g/day) |
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The investigators will assess vastus lateralis muscle thickness using B-mode ultrasound, with participants in a supine position. This measurement will also serve as an indirect indicator of muscle damage through cell swelling. The measurement site will be located at 10% of the thigh circumference lateral to the midpoint between the iliac crest and the superior border of the patella.
| Changes from baseline to week 12 |
| Gait speed | Gait speed will be assessed as a measure of physical function. | From baseline to week 12 |
| Fatty Acid Composition | A venous blood sample (15 ml) will be collected from an antecubital vein by a trained member of the research team and analysed for erythrocyte fatty acid profile. | From baseline to week 12 |
| Inflammatory and metabolic markers | A venous blood sample (15 ml) will be collected by a trained member of the research team from an antecubital vein and analysed to estimate plasma glucose, lipids (triacylglycerol, total cholesterol, HDL), and markers of inflammation (e.g., hsCRP, IL-6, TNF-α, homocysteine). | From baseline to week 12 |
| Height | Height recorded using a stadiometer in centimetre at the beginning of the study. | Changes from baseline to week 12 |
| Bodyweight | Changes in bodyweight, recorded in kilogram. Measured via body composition analyser. | Changes from baseline to week 12 |
| Body Mass Index (BMI) | Will be calculated from the bodyweight (in kilogram) and height (in meter) according to the BMI formula (kg/m^2). | Changes from baseline to week 12 |
| Body Fat Mass | Changes in body fat mass, recorded in kilogram. Measured via body composition analyser. | Changes from baseline to week 12 |
| Body Fat Percentages | Changes in body fat percentage, recorded in percentage. Measured via body composition analyser. | Changes from baseline to week 12 |
| Fat Free Mass | Changes in fat free mass, recorded in kilogram. Measured via body composition analyser. | Changes from baseline to week 12 |
| University of Glasgow | Not yet recruiting | Glasgow | Lanarkshire | G12 8TA | United Kingdom |
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