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Evaluation of the effect of hyaluronic acid with hydroxyapatite versus hydroxyapatite alone on bone regeneration following enucleation of mandibular odontogenic cyst.
During cyst enucleation , There's resultant decrease in bone density especially in large defects .Therefore, it may be needed for a bone grafts and bone regenerative materials to improve quality of bone .The rationale is to evaluate hyaluronic acid with hydroxyapatite as a bone quality improvement material following cyst enucleation, which would provide significant bone regeneration. Hydroxyapatite is inorganic component of bone tissue used as bone graft, scaffolds, filler and cement for repair and regeneration of bone defect , and it is stimulate bone remodeling by generating surface active moieties or cell signaling process while Hyaluronic acid and it's derivatives has been widely used for bone regeneration and it has a good potential for osteogenesis and mineralization
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Hyaluronic acid + Hydroxyapatite | Experimental | hyaluronic acid is used for bone regeneration and it has a good potential for osteogenesis and mineralization so it can have synergistic effect when used with hydroxyapatite for bone regeneration after cyst enucleation |
|
| Hydroxyapatite alone | Active Comparator | Hydroxyapatite is inorganic component of bone tissue used as bone graft, scaffolds, filler and cement for repair and regeneration of bone defect , and it stimulates bone remodeling by generating surface active moieties or cell signaling process |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| hyaluronic acid added to hydroxyapetite | Procedure |
|
| Measure | Description | Time Frame |
|---|---|---|
| Bone density | It is assessed using CBCT to determine the density of bone after intervention | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| postoperative pain | It is assessed by using visual analogue scale from 1-10 | 2 weeks |
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Inclusion Criteria:
Exclusion criteria :
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Enas Eldaour, BSc. | Contact | 01016676513 | +2 | enas.fadel@dentistry.cu.edu.eg |
| Rasha Tohamy, BSc. | Contact | 01066534079 | +2 | rasha.tohamy@dentistry.cu.edu.eg |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Dentistry, Cairo University | Cairo | 12311 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27007721 | Background | Zhao N, Wang X, Qin L, Zhai M, Yuan J, Chen J, Li D. Effect of hyaluronic acid in bone formation and its applications in dentistry. J Biomed Mater Res A. 2016 Jun;104(6):1560-9. doi: 10.1002/jbm.a.35681. Epub 2016 Apr 9. | |
| 22041117 | Background | Scariot R, da Costa DJ, Rebellato NL, Muller PR, Gugisch RC. Treatment of a large dentigerous cyst in a child. J Dent Child (Chic). 2011 Jul;78(2):111-4. |
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| ID | Term |
|---|---|
| D001851 | Bone Diseases, Metabolic |
| ID | Term |
|---|---|
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D017886 | Durapatite |
| ID | Term |
|---|---|
| D006882 | Hydroxyapatites |
| D001031 | Apatites |
| D002130 | Calcium Phosphates |
| D010710 | Phosphates |
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|
| Hydroxyapatite alone | Procedure |
|
|
| 30729045 | Background | AboulHosn M, Noujeim Z, Nader N, Berberi A. Decompression and Enucleation of a Mandibular Radicular Cyst, Followed by Bone Regeneration and Implant-Supported Dental Restoration. Case Rep Dent. 2019 Jan 9;2019:9584235. doi: 10.1155/2019/9584235. eCollection 2019. |
| D010756 |
| Phosphoric Acids |
| D017976 | Phosphorus Acids |
| D000148 | Acids, Noncarboxylic |
| D000143 | Acids |
| D007287 | Inorganic Chemicals |
| D017610 | Calcium Compounds |
| D008903 | Minerals |
| D017553 | Phosphorus Compounds |