Impact of Hyaluronic Acid and Bone Graft on Peri-Implant Tissue

Impact of Hyaluronic Acid and Bone Graft on PeriImplant Tissue Phenotype."A Randomized Controlled Trial"

This randomized controlled clinical trial aims to evaluate the effect of hyaluronic acid (HA) and particulate bone graft on the peri-implant tissue phenotype in patients receiving dental implants. Healthy adult participants requiring dental implant placement will be randomly allocated into one of three equal groups (12 implants per group): Group 1 will receive dental implants combined with hyaluronic acid gel (Gengigel); Group 2 will receive dental implants combined with both hyaluronic acid and particulate bone graft; and the control group will receive dental implants alone.

Clinical and radiographic assessments will be performed using a customized measurement stent to ensure standardized evaluations at baseline, immediately postoperatively, and at 8 and 16 weeks of follow-up. The primary and secondary outcomes include alterations in ridge width, keratinized tissue width/thickness, radiographic soft tissue height, and marginal bone height. The study aims to determine whether the adjunctive use of hyaluronic acid and bone grafts enhances the quality of the peri-implant soft and hard tissue phenotype.

Inclusion Criteria:

• Adults ≥ 18 years old.
• Partially edentulous patients requiring dental implant placement.
• Good oral hygiene (Calibrated Gingival Bleeding Index (GBI) < 10%, O'Leary ---Plaque Index (PI) < 10%).
• Sufficient bone volume for implant placement.

Exclusion Criteria:

• Systemic conditions affecting bone healing (e.g., uncontrolled diabetes).
• Smoking > 10 cigarettes/day.
• Medications affecting bone metabolism (e.g., bisphosphonates).
• Active periodontal disease.
• Pregnant or lactating women.