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Each patient will receive 2 prefabricated CAD-CAM allogeneic bone blocks sterilized with gamma rays with different rehydration methods.
Side I: prefabricated CAD-CAM allogeneic bone block sterilized with gamma rays hydrated using hyaluronic acid * Side II: prefabricated CAD-CAM allogeneic bone block sterilized with gamma rays hydrated using saline solution Both blocks are fixed with osteosynthesis screws, covered with non resorbable membranes** The membranes will be removed after 6 months, dental implants will be placed and core biopsy will be collected from the site of the implant placement for histologic evaluation
10 patients will be included in this study with bilateral atrophic posterior mandible for split mouth research
. group I: prefabricated CAD-CAM allogeneic bone block sterilized with gamma rays hydrated using hyaluronic acid group II: prefabricated CAD-CAM allogeneic bone block sterilized with gamma rays hydrated using saline solution under LA mucoperiosteal flap will be elevated to expose the atrophic ridge then the prefabricated CAD-CAM allogenic block either mixed with hyaluronic acid (group I) or saline (group II) will be fixed in its position with titanium miniscrews , The block was coated with a nonporous d-PTFE membrane then closure of flap with nylon second stage: 6 months later exposure of alveolar ridge core biopsy was taken for histological study then insertion of titanium implants.
the aim of the study is to investigate the effect of hyaluronic acid on a prefabricated CAD- CAM bone blocks for ridge augmentation radiographically and histologically.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| prefabricated CAD-CAM allogeneic bone block hydrated using hyaluronic acid | Experimental | mucoperiosteal flap will be elevated to expose the atrophic ridge then the prefabricated CAD-CAM allogenic block will be fixed in its position with titanium miniscrews , The block was coated with a nonporous d-PTFE membrane |
|
| prefabricated CAD-CAM allogeneic bone block sterilized hydrated using saline solution | Experimental | mucoperiosteal flap will be elevated to expose the atrophic ridge then the prefabricated CAD-CAM allogenic block will be fixed in its position with titanium miniscrews ,The block was coated with a nonporous d-PTFE membrane |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| prefabricated CAD-CAM allogeneic bone block hydrated using hyaluronic acid | Procedure | exposure of atrophic posterior mandibular ridge, augmentation with CAD-CAM prefabricated allogenic bone block which fixed with titanium screws ,The block was coated with a nonporous d-PTFE membrane |
| Measure | Description | Time Frame |
|---|---|---|
| measurement the width and the height of the alveolar ridge | using CBCT the width and the height will be measured with measuring tools in milimeter (mm) | 6 months |
| the amount of new bone formation | core biopsy will be underwent histomorphometric analysis to determine the percentage of new bone formation (%) | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| the sucess of dental implants | usingCBCT to determine the amount of marginal bone loss in (mm) | 12 months |
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Inclusion criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| mohamed h helal, lecturer | Tanta University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Dentistry, Tanta University | Tanta | 3111 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40231349 | Derived | Helal MH, Sheta MS, Alsherif AA, Hassan MA, Aboushelib MN, Ghouraba RF. The Effectiveness of Hyaluronic Acid on Prefabricated CAD CAM Bone Blocks for Ridge Augmentation: A Split Mouth Study. Clin Implant Dent Relat Res. 2025 Apr;27(2):e70035. doi: 10.1111/cid.70035. |
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parallel assignment
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using closed envelop for participants the data will be given to outcomes assessors without defining the intervention for each group
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| prefabricated CAD-CAM allogeneic bone block sterilized hydrated using saline solution | Procedure | exposure of atrophic posterior mandibular ridge, augmentation with CAD-CAM prefabricated allogenic bone block which fixed with titanium screws. The block was coated with a nonporous d-PTFE membrane |
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