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The aim of this study is to evaluate the effects of hyaluronic acid (HA) on bone healing in human dental sockets.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| hyaluronic acid | Experimental | Immediately after the extractions, one socket was randomly filled with 1% hyaluronic acid gel. |
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| Blood clot | Placebo Comparator | Immediately after the extractions, the other side socket was naturally filled with blood clot. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| hyaluronic acid | Drug |
|
| |
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of bone formation | During the postoperative interval of 30 days, the patients underwent cone beam computed tomography (CBCT). Five central transverse scan images were captured from each socket. Using the KS300 software, the gray intensity was measured in each image and the results were expressed as mean percentage of bone formation | 30 days after extraction and treatment application |
| Fractal dimension | During the postoperative interval of 30 days, the patients underwent cone beam computed tomography (CBCT). Five central transverse scan images were captured from each socket. The pattern of the alveolar trabecular bone was also evaluated through the fractal dimension in each image. | 30 days after extraction and treatment application |
| Dimensional Alveolar changes | To determine whether treatment could prevent loss of buccolingual thickness, was compared bone loss of 90 to 30 days between the treated and control groups. | 30 to 90 days after extraction and treatment application |
| Percentage of bone formation | During the postoperative interval of 90 days, the patients underwent cone beam computed tomography (CBCT). Five central transverse scan images were captured from each socket. Using the KS300 software, the gray intensity was measured in each image and the results were expressed as mean percentage of bone formation | 90 days after extraction and treatment application |
| Fractal dimension | During the postoperative interval of 90 days, the patients underwent cone beam computed tomography (CBCT). Five central transverse scan images were captured from each socket. The pattern of the alveolar trabecular bone was also evaluated through the fractal dimension in each image. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Anderson Ferreira, Professor | Instituto de Ciências Biológicas - Universidade Federal de Minas Gerais | Study Director |
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| ID | Term |
|---|---|
| D016301 | Alveolar Bone Loss |
| ID | Term |
|---|---|
| D001862 | Bone Resorption |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D055093 | Periodontal Atrophy |
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| ID | Term |
|---|---|
| D006820 | Hyaluronic Acid |
| ID | Term |
|---|---|
| D006025 | Glycosaminoglycans |
| D011134 | Polysaccharides |
| D002241 | Carbohydrates |
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| Placebo |
| Other |
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| 90 days after extraction and treatment application |
| D010510 |
| Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |