The present prospective clinical study will be undertaken for assessment of two different modalities of maxillary canine retraction assisted with injectable platelet rich fibrin.

Inclusion Criteria:

• An age range from 15-22 years.
• Severe crowding or protrusion requiring 1st premolars extractions followed by symmetrical canine retraction.
• All permanent teeth present, 3rd molars are excluded.
• Good oral and general health.
• No systemic disease/medication that could interfere with OTM. No previous orthodontic treatment.

Exclusion Criteria:

• Patient diagnosed to have an indication for non-extraction approach.
• Poor oral hygiene or periodontally compromised patient.
• Patient with craniofacial anomalies or previous history of trauma, bruxism or parafunctions.