The Effect of Multiple Injections of (PRF) on The Rate of Canine Retraction

The Effect of Multiple Injections of Platelets Rich Fibrin (i-PRF) on The Rate of Canine Retraction A Split-mouth: A Randomized Controlled Trial

this clinical trial aims to prove that multiple injections will produce a steady rate of acceleration of orthodontic tooth movement.

Platelet-rich fibrin injection is a second-generation platelet concentrate, prepared from centrifuged blood which is a rich source of platelets, stem cells, and growth factors seven times greater than that released by platelet-rich plasma. It is a simplified procedure with no biochemical manipulation of blood, free from anticoagulants which are known to inhibit wound healing or any gelling agent, and easily usable with a low rate of mistakes during the preparation procedure.

A variety of growth factors are released by PRF such as platelet-derived growth factor (PDGF), transforming growth factor β (TGF-β), and vascular endothelial growth factor (VEGF), which play a crucial role in angiogenesis, collagen synthesis, and bone regeneration.

Treatment with extraction especially in adult patients may take a longer time due to reported increase in bone density and lower bone regenerative rate. Also, the retraction process to close extraction spaces most of the time is accompanied by bone loss and root resorption as reported in the previous studies. i-PRF can accelerate tooth movement, in addition, prevent tooth retraction undesirable side effects.

Inclusion Criteria:

• adult patient
• Full set of permanent dentition (excluding third molars).
• Good oral hygiene
• protrusion cases that require extraction of premolars (Bimaxillary protrusion or class II div 1)

Exclusion Criteria:

• History of previous orthodontic treatment.
• Systemic disease or drugs affecting tooth movement.
• Smokers
• Poor oral health that precludes orthodontic treatment (presence of caries, active white spots, or periodontal diseases)
• Severe crowding cases with ectopic erupted canines