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This study evaluated the effect of injectable platelet-rich derivatives on the rate of orthodontic canine retraction. Patients requiring orthodontic canine retraction following premolar extraction were enrolled and divided into three groups using a split-mouth design. Injectable platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) were applied to compare their effects on the rate of tooth movement. The outcomes were assessed by measuring the amount of canine retraction over time.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PRP vs Control (Split-Mouth) | Experimental | Split-mouth group in which one side received platelet-rich plasma (PRP) injection and the contralateral side served as a control without injection during orthodontic canine retraction. |
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| PRF vs Control (Split-Mouth) | Experimental | Split-mouth group in which one side received platelet-rich fibrin (PRF) injection and the contralateral side served as a control without injection during orthodontic canine retraction. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Platelet-Rich Plasma (PRP) | Biological | Autologous platelet-rich plasma prepared from the patient's own blood and injected locally at the experimental side to accelerate orthodontic canine retraction. |
| Measure | Description | Time Frame |
|---|---|---|
| Rate of Orthodontic Canine Retraction | The amount of orthodontic canine movement measured in millimeters. | From baseline (initiation of orthodontic canine retraction) until completion of canine retraction, assessed monthly for up to 4 months. |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Dentistry, Sana'a University | Sanaa | Yemen |
Individual participant data will not be shared because this study was conducted as part of a master's degree thesis and the data are subject to institutional and ethical restrictions.
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Split-mouth randomized controlled design in which different interventions were applied to opposite sides within the same participant.
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| Platelet-Rich Fibrin (PRF) | Biological | Autologous platelet-rich fibrin prepared from the patient's own blood and injected locally to accelerate orthodontic canine retraction. |
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