Effect of Injectable Platelet Rich Derivatives on Orthodontic Canine Retraction

The Effect of Injectable Platelet Rich Derivatives on the Rate of Orthodontic Canine Retraction: A Split-Mouth Randomized Controlled Trial

This study evaluated the effect of injectable platelet-rich derivatives on the rate of orthodontic canine retraction. Patients requiring orthodontic canine retraction following premolar extraction were enrolled and divided into three groups using a split-mouth design. Injectable platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) were applied to compare their effects on the rate of tooth movement. The outcomes were assessed by measuring the amount of canine retraction over time.

Inclusion Criteria:

• Healthy individuals aged 17-29 years (mean age 24 ± 6 years)
• Diagnosis of Class I bimaxillary protrusion or Class II division 1 requiring first premolar extractions
• Full permanent dentition
• Good oral hygiene
• Non-smokers
• Not taking medications affecting bone metabolism (e.g., bisphosphonates)

Exclusion Criteria:

• Pregnancy or breastfeeding
• Contraindications to platelet therapies (e.g., platelet dysfunction)
• Severe malocclusion unsuitable for fixed appliances
• Dental anomalies (size/shape)
• Systemic syndromes