Effect of Probiotics on Oral Candida Among Denture Wearers

Effect of Probiotics on Oral Candida Colonization Level in Complete Denture Wearers (Randomized Controlled Clinical Trial)

Forty-eight denture wearers with detectable levels of candida colonization without clinical symptoms will be randomly allocated into two groups: probiotics and placebo. All patients will take a daily dose of chewable tablets (probiotics or placebo according to the assigned group) for 8 weeks. Samples of mouth rinse will be collected from patients at baseline, 4 weeks from the beginning of the intervention, 8 weeks (the end of intervention), and after another 4 weeks for post-intervention follow up. Samples will be tested for both candida count and candida species identification

Inclusion Criteria:

• Detectable levels of Candida in palatal mucosa without clinical symptoms of active candidiasis.
• Completely edentulous arches with newly formed denture .
• Patients with controlled hypertension, and diabetes will be included in this study as they are considered very common problems in the targeted population.

Exclusion Criteria:

• Inability to understand/ follow the experimental procedures,
• Administration of topic or systemic antifungal or antibacterial agents in the previous 60 days.
• Consumption of probiotics.
• GITdisorders.
• Heartdisease.
• Diseases that significantly influence immunity such as; kidney problems, head and neck cancer, or radiotherapy, AIDS, or immunosuppressive therapy.
• Clinical manifestations of oral candidiasis.