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The aim of this study is to investigate the effect of daily intake of the probiotic Lactobacillus Reuteri on the prevalence and counts of oral Candida in frail elderly living in nursery homes.
The aim of the present study was to investigate the effect of a twice daily intake of lozenges containing probiotic Lactobacillus reuteri on the prevalence and counts of oral Candida in senior residents living in nursery homes. The material consists of 215 elderly persons (range 60 to 102 years) living in 20 different nursery homes in the County of Kronoberg, situated in the southern parts of Sweden. The subjects were consecutively enrolled after informed consent consisting of verbal and written information directed to the individual as well as to their relatives. The study employed a double-blind randomized placebo-controlled design.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| L. reuteri DSM 17938/ATCC PTA | Active Comparator | L. reuteri DSM 17938/ATCC PTA lozenges twice daily for 12 weeks |
|
| Placebo | Placebo Comparator | Placebo lozenges twice daily for 12 weeks |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| L. reuteri DSM 17938/ATCC PTA | Dietary Supplement | Ingestion of active lozenge twice daily for 12 weeks |
|
| Measure | Description | Time Frame |
|---|---|---|
| Prevalence of oral Candida growth assessed from chair-side tests. | Saliva and plaque samples will be analyzed and data presented when all 215 participants have completed the intervention period. | Baseline and 12 weeks. |
| Amount of oral Candida growth assessed from chair-side tests. | Saliva and plaque samples will be analyzed and data presented when all 215 participants have completed the intervention period. | Baseline and 12 weeks. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in levels of dental plaque | Secondary Outcome Measures will be measured before and after the intervention period. | Baseline and 12 weeks. |
| Changes in levels of gingival bleeding. | Secondary Outcome Measures will be measured before and after the intervention period. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Svante Twetman, Professor | University of Copenhagen | Study Director |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26202995 | Derived | Kraft-Bodi E, Jorgensen MR, Keller MK, Kragelund C, Twetman S. Effect of Probiotic Bacteria on Oral Candida in Frail Elderly. J Dent Res. 2015 Sep;94(9 Suppl):181S-6S. doi: 10.1177/0022034515595950. Epub 2015 Jul 22. |
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| ID | Term |
|---|---|
| D002177 | Candidiasis |
| ID | Term |
|---|---|
| D009181 | Mycoses |
| D001423 | Bacterial Infections and Mycoses |
| D007239 | Infections |
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| Placebo | Dietary Supplement | Ingestion of placebo lozenge twice daily for 12 weeks |
|
| Baseline and 12 weeks. |