Effect of Probiotics on Oral Homeostasis During Oral Hygiene Discontinuation
Effect of Probiotics on Oral Homeostasis During Oral Hygiene Discontinuation
The present study is a double-blinded randomized clinical trial with a duration of 28 days.
The present study is a double-blinded randomized clinical trial with a duration of 28 days.
80 orally and systemically healthy participant will be allocated in the test (probiotic) and the control (placebo) group at baseline.
The intervention is oral hygiene discontinuation, which will be applied at baseline and continue through day 14, followed by 14 days with regular oral care.
Clinical measurements and sampling will be performed at baseline, day 14 and day 28
Primary endpoint: Changes in microbial composition.
Secondary endpoints: Changes in clinical and immunological parameters
Inclusion Criteria:
- age > 18 yrs.
Exclusion Criteria: