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The aim of this study is to evaluate the effect of PIP toothbrush cleaner® on the microbial composition and Candida albicans colonization of denture biofilm formation. Additionally, its effect will be compared to that of cleansing tablets.
Therefore the present study intended to compare a probiotic denture cleaning protocol with the current protocols. It was aimed to examine, in institutionalized older individuals with removable complete dentures, if the microbial composition and C. albicans colonization of the denture biofilm differs when overnight stored in a probiotic cleaning product compared to water or a cleanser. Additionally the influence of brushing on these protocols was investigated.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Immersion in water | Other | water |
|
| Immersion in water + cleansing tablet | Active Comparator | Corega Tabs Anti-bacteria® (GlaxoSmithKline Consumer Healthcare SA, Genval, Belgium) |
|
| Immersion in water with PIP | Experimental | PIP toothbrush cleaner® (Chrisal, Lommel, Belgium) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PIP toothbrush cleaner® (Chrisal, Lommel, Belgium). | Drug | Probiotic |
|
| Measure | Description | Time Frame |
|---|---|---|
| Candida albicans colonization | C. albicans colonization was the primary outcome measure of interest. With a microbial test there was researched if C. albicans colonized the prostheses. | day 5 |
| Measure | Description | Time Frame |
|---|---|---|
| Other microbiological counts Aa | The concentration of Aggregatibacter Actinomycetemcomitans was researched. | day 5 |
| Other microbiological counts Pg | The concentration of Porphyromonas gingivalis was researched. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Joke Duyck, DDS, PhD | Universitaire Ziekenhuizen KU Leuven | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Oral Health Sciences | Leuven | 3000 | Belgium |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23948391 | Background | Duyck J, Vandamme K, Muller P, Teughels W. Overnight storage of removable dentures in alkaline peroxide-based tablets affects biofilm mass and composition. J Dent. 2013 Dec;41(12):1281-9. doi: 10.1016/j.jdent.2013.08.002. Epub 2013 Aug 13. |
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| ID | Term |
|---|---|
| D009066 | Mouth, Edentulous |
| ID | Term |
|---|---|
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D014076 | Tooth Diseases |
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| ID | Term |
|---|---|
| D019936 | Probiotics |
| D014867 | Water |
| ID | Term |
|---|---|
| D019587 | Dietary Supplements |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
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| Corega Tabs Anti-bacteria® | Drug | Cleansing tablet -Corega Tabs Anti-bacteria® (GlaxoSmithKline Consumer Healthcare SA, Genval, Belgium) |
|
|
| Water | Other | Water |
|
| day 5 |
| Other microbiological counts Tf | The concentration of Tannerella forsythensis was researched. | day 5 |
| Other microbiological counts Td | The concentration of Treponema denticola was researched. | day 5 |
| Other microbiological counts Pi | The concentration of Prevotella intermedia was researched. | day 5 |
| Other microbiological counts Fn | The concentration of Fusobacterium nucleatum was researched. | day 5 |
| Other microbiological counts Pm | The concentration of Peptostreptococcus micros was researched. | day 5 |
| Other microbiological counts Pn | The concentration of Prevotella nigrescens was researched. | day 5 |
| Other microbiological counts Cg | The concentration of Campylobacter gracilis was researched. | day 5 |
| Other microbiological counts Cr | The concentration of Campylobacter rectus was researched. | day 5 |
| Other microbiological counts En | The concentration of Eubacterium nodatum was researched. | day 5 |
| Other microbiological counts Ec | The concentration of Eikenella corrodens was researched. | day 5 |
| Other microbiological counts Capn | The concentration of Capnocytophaga species was researched. | day 5 |
| Other microbiological counts Cc | The concentration of Campylobacter concisus count was researched. | day 5 |
| Other microbiological counts mitis streptococci | Concentration of mitis streptococci | day 5 |
| Other microbiological counts Sg | The concentration of Streptococcus gordonii | day 5 |
| Other microbiological counts Sc | The concentration of Streptococcus constellatus. | day 5 |
| Other microbiological counts Ao | The concentration of Actinomyces odontolyticus. | day 5 |
| Other microbiological counts Av | The concentration of Actinomyces viscosus. | day 5 |
| Other microbiological counts Vp | The concentration of Veillonella parvula. | day 5 |
| Other microbiological counts total | Total bacterial count. | day 5 |
| D019602 |
| Food and Beverages |
| D006878 | Hydroxides |
| D000468 | Alkalies |
| D007287 | Inorganic Chemicals |
| D000838 | Anions |
| D007477 | Ions |
| D004573 | Electrolytes |
| D010087 | Oxides |
| D017601 | Oxygen Compounds |