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The aim of this study was evaluate the effects of the oral probiotic Lactobacillus reuteri Prodentis upon the peri-implant health of edentulous patients with dental implants and peri-implant mucositis, establishing comparisons versus implants without peri-implant disease. The hypothesis of the study is that using these probiotics are going to improve the periimplant health.
A double-blind, placebo-controlled, prospective cross-over study was made. All the patients were edentulous and were divided into two groups: A) with no peri-implant disease; B) with peri-implant mucositis affecting one or more implants. Patients with peri-implantitis were excluded. All patients in both groups initially received the oral probiotic Lactobacillus reuteri Prodentis, followed by placebo. Only the supervisor of the study knew this information; clinical examiner and patients were blind. Were studied: crevicular fluid volume, modified plaque index, probing depth, modified gingival index, and concentrations of interleukin 1β, interleukin 6 and interleukin 8, and Bacterial load.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Probiotic Lactobacillus reuteri Vs Placebo | Experimental | patients with full arch with dental implant received a tablet of Lactobacillus reuteri every day during 28 days, and after a wash-up, the same patients receive a tablet of placebo every day during 28 days |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Probiotic tablets of Lactobacillus reuteri | Dietary Supplement |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| Evidence in reduction of plaque index | The Mombelli clasification was used to evaluate the reduction of bacterial plaque. 0: No bacterial plaque; 1: presence of bacterial plaque but not visually; 2: 1/3 part of the implant with bacterial plaque; 3: 2/3 parts or more of the implant with bacterial plaque | 28 days using one probiotic tablet/day |
| Measure | Description | Time Frame |
|---|---|---|
| Evidence in reduction of bleeding around implants | The Mombelli classification was used to evaluate the reduction of bleeding around implants: 0: no bleeding; 1: a point of bleeding; 2)a line of bleeding; 3: much bleeding | 28 days using probiotic tablet/day |
| Evidence in reduction of probing depth |
| Measure | Description | Time Frame |
|---|---|---|
| Evidence of reduction of Total Bacterial Load studied | Where evaluate Aggregatibacter and red complex of socransky | 28 days using probiotic tablets/day |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Oral Surgery, University of Valencia | Valencia | Valencia | 46010 | Spain |
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| ID | Term |
|---|---|
| D052016 | Mucositis |
| ID | Term |
|---|---|
| D005759 | Gastroenteritis |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
| D009059 | Mouth Diseases |
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| ID | Term |
|---|---|
| D019936 | Probiotics |
| D005421 | Flavoring Agents |
| ID | Term |
|---|---|
| D019587 | Dietary Supplements |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
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| Placebo tablets | Dietary Supplement |
|
|
Was measured in reduction of millimeters of the depth of the implant with a millimeter probe. |
| 28 days using one probiotic tablet/day |
| Evidence in reduction Interleukin 1β concentration | concentration measured in picograms/milliliter (pg/ml) | 28 days using one probiotic tablet/day |
| Evidence in reduction Interleukin 6 concentration | concentration measured in picograms/milliliter (pg/ml) | 28 days using one probiotic tablet/day |
| Evidence in reduction Interleukin 8 concentration | concentration measured in picograms/milliliter (pg/ml) | 28 days using one probiotic tablet/day |
| D009057 |
| Stomatognathic Diseases |
| D019602 |
| Food and Beverages |
| D010592 | Pharmaceutic Aids |
| D004364 | Pharmaceutical Preparations |
| D005503 | Food Additives |
| D000074385 | Food Ingredients |
| D020313 | Specialty Uses of Chemicals |
| D020164 | Chemical Actions and Uses |