Effect of Probiotics as Supplement to Non-surgical Periodontal Treatment
Effect of Probiotics as Supplement to Non-surgical Periodontal Treatment
The present study is a double-blinded randomized clinical trial with a duration of 12 weeks.
The present study is a double-blinded randomized clinical trial with a duration of 12 weeks
. 60 patients with periodontitis stage 2-3, grade B-C, generalized will be allocated in the test (probiotic) and the control (placebo) group at baseline.
The intervention is non-surgical periodontal treatment, which will be applied at baseline and followed for 12 weeks.
Clinical measurements and sampling will be performed at baseline, week 6 and week 12.
Primary endpoint: Changes in microbial composition.
Secondary endpoints: Changes in clinical and immunological parameters
Inclusion Criteria:
Exclusion Criteria: