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To assess the efficacy of Pitaya Ovule Extract on skin
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo drink | Placebo Comparator |
| |
| Pitaya Ovule Extract Drink | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Placebo drink | Dietary Supplement | consume 1 bottle per day |
| |
| Measure | Description | Time Frame |
|---|---|---|
| The change of L* (lightness) values | Spectrophotometer SCM-108 was utilized to measure skin L* value. Units: arbitrary units | Change from Baseline L* value at 8 weeks |
| The change of skin elasticity | Cutometer® Dual MPA580 was utilized to measure skin elasticity. Units: arbitrary units | Change from Baseline skin elasticity at 8 weeks |
| The change of skin collagen density | DermaLab® Combo Ultrasound module was utilized to measure skin collagen density. Units: arbitrary units | Change from Baseline skin collagen density at 8 weeks |
| The change of skin wrinkles | IRV skin analyzer was utilized to measure skin wrinkles. Units: arbitrary units | Change from Baseline skin wrinkles at 8 weeks |
| The change of skin texture | IRV skin analyzer was utilized to measure skin texture. Units: arbitrary units | Change from Baseline skin texture at 8 weeks |
| The change of skin pores | IRV skin analyzer was utilized to measure skin pores. Units: arbitrary units | Change from Baseline skin pores at 8 weeks |
| The change of skin tone | IRV skin analyzer was utilized to measure skin tone. Units: arbitrary units | Change from Baseline skin tone at 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| The change of liver function biomarkers (AST, ALT) of blood | Venous blood was sampled to measure liver function biomarkers | Change from Baseline liver function biomarkers at 8 weeks |
| The change of renal function biomarkers (creatinine, BUN) of blood |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hsiu-Mei Chiang, Prof. | China Medical University, China | Principal Investigator |
| Po-Yuan Wu, Dr. | China Medical University Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| China Medical University | Taichung | Taiwan |
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| ID | Term |
|---|---|
| D012871 | Skin Diseases |
| ID | Term |
|---|---|
| D017437 | Skin and Connective Tissue Diseases |
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| Pitaya Ovule Extract Drink |
| Dietary Supplement |
consume 1 bottle per day |
|
| The change of Advanced glycation end products of blood | Venous blood was sampled to measure AGEs | Change from Baseline AGEs at 8 weeks |
| The change of RAGE (receptor for advanced glycation end products) of blood | Venous blood was sampled to measure RAGE | Change from Baseline RAGE at 8 weeks |
| The change of Matrix metalloproteinases (MMP-2, MMP-9) of blood | Venous blood was sampled to measure MMPs | Change from Baseline MMPs at 8 weeks |
Venous blood was sampled to measure renal function biomarkers
| Change from Baseline renal function biomarkers at 8 weeks |
| The change of fasting blood glucose level | Venous blood was sampled to measure fasting blood glucose level | Change from Baseline fasting blood glucose level at 8 weeks |
| Change from Baseline insulin level at 8 weeks | Venous blood was sampled to measure insulin level | Change from Baseline insulin level at 8 weeks |
| The change of blood lipid profile | Venous blood was sampled to measure blood lipid profile (total cholesterol, HDL-C, LDL-C, triglyceride) | Change from Baseline blood lipid profile at 8 weeks |