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Evaluate the effects of blood peach extract drink and rose apple extract drink on enhancing hemoglobin and iron levels, and improving skin health.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Placebo Comparator |
| |
| Blood Peach Extract | Experimental |
| |
| Rose Apple Extract | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Placebo Drink | Dietary Supplement | Take one bottle of the product every morning on an empty stomach |
|
| Measure | Description | Time Frame |
|---|---|---|
| the volume of skin wrinkles | IRV full-face skin analyzer was utilized to measure skin wrinkles. Units: arbitrary units | Volume change from Baseline skin wrinkles at 8 weeks |
| the roughness of skin texture | IRV full-face skin analyzer was utilized to measure skin texture. Units: arbitrary units | Rating skin roughness from Baseline skin texture at 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| the change of skin elasticity | Cutometer® was utilized to measure skin elasticity. Units: arbitrary units | Change from Baseline skin elasticity at 8 weeks |
| the change of skin collagen density | Dermalab® Combo was utilized to measure skin collagen density. Units: arbitrary units |
| Measure | Description | Time Frame |
|---|---|---|
| the change of liver function biomarkers (AST, ALT) of blood | venous blood was sampled to measure liver function biomarkers | change from Baseline liver function biomarkers at 8 weeks |
| the change of renal function biomarkers (creatinine, BUN) of blood |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hsiu-Mei Chiang | China Medical University of Department of Cosmeceutics | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| China Medical University of Department of Cosmeceutics | Taichung | 406040 | Taiwan |
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| Blood Peach Extract Drink | Dietary Supplement | Take one bottle of the product every morning on an empty stomach |
|
| Rose Apple Extract Drink | Dietary Supplement | Take one bottle of the product every morning on an empty stomach |
|
| Change from Baseline skin collagen density at 8 weeks |
| the change of skin pores | IRV full-face skin analyzer was utilized to measure skin pores. Units: arbitrary units | Change from Baseline skin pores at 8 weeks |
| the change of skin tone | IRV full-face skin analyzer was utilized to measure skin tone. Units: arbitrary units | Change from Baseline skin tone at 8 weeks |
| the change of skin hydration | Corneometer® was utilized to measure skin hydration. Units: arbitrary units | Change from Baseline skin hydration at 8 weeks |
| the change of skin melanin/erythema index | Mexameter® was utilized to measure skin melanin/erythema index. Units: arbitrary units | Change from Baseline skin melanin/erythema index at 8 weeks |
| the change of skin redness | Colorimeter was utilized to measure skin redness. Units: arbitrary units | Change from Baseline skin redness at 8 weeks |
| the change of lip redness | Antera 3D® was utilized to measure lip redness. Units: arbitrary units | Change from Baseline lip redness at 8 weeks |
| the change of Red Blood Cells (RBC) Count of blood | venous blood was sampled to measure RBC count | Change from Baseline RBC count at 8 weeks |
| the change of hemoglobin level of blood | venous blood was sampled to measure hemoglobin level | Change from Baseline hemoglobin level at 8 weeks |
| the change of mean corpuscular volume (M.C.V) level of blood | venous blood was sampled to measure M.C.V level | Change from Baseline M.C.V level at 8 weeks |
| the change of mean corpuscular hemoglobin concentration (M.C.H.C) level of blood | venous blood was sampled to measure M.C.H.C level | Change from Baseline M.C.H.C level at 8 weeks |
| the change of ferrous level of blood | venous blood was sampled to measure ferrous level | Change from Baseline ferrous level at 8 weeks |
| the change of ferritin level of blood | venous blood was sampled to measure ferritin level | Change from Baseline ferritin level at 8 weeks |
| the change of Total Iron Binding Capacity (TIBC) level of blood | venous blood was sampled to measure TIBC level | Change from Baseline TIBC level at 8 weeks |
| the change of unsaturated iron-binding capacity (UIBC) level of blood | venous blood was sampled to measure UIBC level | Change from Baseline UIBC level at 8 weeks |
venous blood was sampled to measure renal function biomarkers
| change from Baseline renal function biomarkers at 8 weeks |
| the change of fasting glucose level of blood | venous blood was sampled to measure fasting glucose level | change from Baseline fasting glucose level at 8 weeks |
| the change of Advanced glycation end products (AGEs) level of blood | venous blood was sampled to measure AGEs level | change from Baseline AGEs level at 8 weeks |
| The change of self-assessment skin and metabolic circulation condition | A self-assessment questionnaire was collected to evaluate skin and metabolic circulation condition. As for the evalutation of skin condition, the higher score the better; As for evaluation of metabolic circulation condition, the higher score the worse. | Change from Baseline skin and metabolic circulation condition at 8 weeks |