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The impact of hypoxia on maximal work rate during incremental ramp exercise within 3-6 hours after arriving at 2500m of high altitude in patients with precapillary pulmonary hypertension
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High altitude 2500 m above sea level (high altitude) | Experimental | Maximum Exercise Capacity in high altitude |
|
| Low altitude 470 m above sea level (low altitude) | Active Comparator | Maximum Exercise Capacity in low altitude |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Maximal Exercise Capacity | Procedure | Maximal Exercise Capacity in incremental ramp exercise tests. |
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| Measure | Description | Time Frame |
|---|---|---|
| Maximal work rate | Change in maximal work rate in Watt at 2500 vs. 490 m | 30 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Heart rate | Change in cardiorespiratory measurements: heart rate during a cycle incremental ramp exercise test at high altitude vs. low altitude | 30 hours |
| Ventilation | Change in cardiorespiratory measurements: ventilation during a cycle incremental ramp exercise test at high altitude vs. low altitude |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Respiratory Clinic, University Hospital of Zurich | Zurich | 8091 | Switzerland |
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| ID | Term |
|---|---|
| C535833 | Pulmonary edema of mountaineers |
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Patients will be exposed to ambient air at 490m vs. hypoxic air at 2500m in a randomized sequence according to a cross-over design
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| 30 hours |
| Oxygen uptake | Change in cardiorespiratory measurements: Oxygen uptake, SpO2, blood gases during a cycle incremental ramp exercise test at high altitude vs. low altitude | 30 hours |
| Arterial blood oxygenation saturation | Change in cardiorespiratory measurements: Oxygenation (SpO2) during a cycle incremental ramp exercise test at high altitude vs. low altitude | 30 hours |
| Blood gases | Change in blood gases during a cycle incremental ramp exercise test at high altitude vs. low altitude | 30 hours |
| Hemodynamics | Change in hemodynamics assessed by echocardiography | 30 hours |
| Borg dyspnoea and leg fatigue scale | Change in post-exercise Borg dyspnoea and leg fatigue scale during a cycle incremental ramp exercise test at high altitude vs. low altitude | 30 hours |
| Visual Analogue Scale for dyspnea | Change Visual Analogue Scale at high altitude vs. low altitude according to a 10cm scale from left to right, where the subject has to mark dyspnea with higher values in cm meaning worse dyspnea | 30 hours |
| Electro cardiography | Prevalence of abnormal resting electro cardiography (ECG) at high altitude vs. low altitude | 30 hours |
| Electro cardiography :ST-segment changes | Difference in ST-segment changes during cycle incremental ramp and constant work-rate exercise tests at high altitude vs. low altitude | 30 hours |
| Electro cardiography: ST-segment changes under oxygen | 7Difference in ST-segment changes during cycle exercise tests without and with oxygen at high altitude | 30 hours |
| Electro cardiography: Clinically relevant ischemia | Incidence of clinically relevant ischemia (>1mm ST-segment depression) during cycle exercise tests at high altitude vs. low altitude | 30 hour |
| Electro cardiography: QT-Interval | Change of corrected QT-Interval, during cycle exercise tests at high vs. low altitude | 30 hours |
| Electro cardiography: QT-Interval | Change of corrected QRS duration, during cycle exercise tests at high vs. low altitude | 30 hours |
| Electro cardiography: PQ-Interval | Change of corrected PQ-Interval, during cycle exercise tests at high vs. low altitude | 30 hours |
| Rate pressure product | Change of corrected Rate pressure product, during cycle exercise tests at high vs. low altitude | 30 hours |
| Electro cardiography: Cardiac arrhythmia | Incidence of cardiac arrhythmia during cycle exercise tests at high altitude vs. low altitude | 30 hours |