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The impact of hypoxia at 2500m of high altitude on sleep in patients with precapillary pulmonary hypertension
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High altitude 2500 m above sea level | Experimental |
| |
| Low altitude 470 m above sea level | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Nocturnal rest (sleep study) | Procedure | Proportion of patients free of severe hypoxemia without oxygen therapy during nocturnal rest . |
|
| Measure | Description | Time Frame |
|---|---|---|
| Proportion of patients free of severe hypoxemia | Proportion of patients free of severe hypoxemia (defined as oxygenation (SpO2)<80% for >30 min) without oxygen therapy during nocturnal rest at 2500 m vs. 490 m | 30 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Nocturnal oxygenation | Difference in mean nocturnal oxygenation (SpO2) 2500 m of high altitude vs 490 m low altitude | 30 hours |
| Oxygen desaturation index | Difference in oxygen desaturation index sleeping at 2500 m high altitude vs 490 m low altitude |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital of Zurich | Zurich | 8091 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40085143 | Derived | Lichtblau M, Schwarz EI, Ulrich T, Schneider SR, Bauer M, Furian M, Carta A, Forrer A, Saxer S, Muller J, Preiss H, Mayer L, Bloch KE, Ulrich S. Effect of an Overnight Stay at 2,500 Meters on Nocturnal Hypoxemia and Sleep-disordered Breathing in Patients with Pulmonary Vascular Disease: A Randomized Clinical Trial. Ann Am Thorac Soc. 2025 Jul;22(7):1053-1061. doi: 10.1513/AnnalsATS.202412-1279OC. |
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| 30 hours |
| Periodic breathing | Difference in time spent with periodic breathing in patients sleeping at 2500 m of high altitude vs 490 m low altitude | 30 hours |
| Nocturnal transcutaneous carbon dioxide tension | Difference in nocturnal transcutaneous carbon dioxide tension in patients sleeping at 2500 m of high altitude vs 490 m low altitude | 30 hours |
| Visual Analogue Scale | Subjective sleep quality Visual Analogue Scale score 2500 m high altitude vs 490 m low altitude | 30 hours |
| Time spent awake during the night | Subjective time spent awake during the night high altitude vs 490 m low altitude | 30 hours |
| Cerebral tissue deoxygenation | Proportion of patients free of severe cerebral tissue deoxygenation (drop in cerebral tissue oxygen saturation >5%) without oxygen therapy during a night at 2500 vs. 490 m | 30 hours |
| Cerebral tissue oxygen saturation awake | Difference in cerebral tissue oxygen saturation awake in patients with precapillary pulmonary hypertension at 2500m of high altitude without supplemental oxygen vs. low altitude | 30 hours |
| Cerebral tissue oxygen saturation during sleep without oxygen | Difference in cerebral tissue oxygen saturation during sleep in patients with precapillary pulmonary hypertension at 2500m of high altitude without supplemental oxygen | 30 hours |
| Cerebral tissue oxygen saturation during sleep with oxygen | Difference in cerebral tissue oxygen saturation during sleep in patients with precapillary pulmonary hypertension at 2500m of high altitude with supplemental oxygen | 30 hours |
| Cerebral oxygen desaturation index without oxygen | Difference in the cerebral oxygen desaturation index in patients with precapillary pulmonary hypertension at 2500m of high altitude without supplemental oxygen vs. low altitude | 30 hours |
| Cerebral oxygen desaturation index with oxygen | Difference in the cerebral oxygen desaturation index in patients with precapillary pulmonary hypertension at 2500m of high altitude under supplemental oxygen. | 30 hours |
| Cerebral tissue oxygen saturation between different sleep stages | Changes in the cerebral tissue oxygen saturation between different sleep stages at 2500 m compared to low altitude. | 30 hours |
| ID | Term |
|---|---|
| C535833 | Pulmonary edema of mountaineers |
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