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The impact of a sojourn at 2500 m of high altitude for 26-30 h on constant work-rate exercise test time in patients with precapillary pulmonary hypertension
Patients with pulmonary hypertension will perform a constant work-rate exercise test at low altitude (450m) and at high altitude 2500m in a randomized-cross-over sequence protocol. The constant work-rate exercise test time and other measures will be assessed
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Constant work-rate at altitude 2500 m above sea level (high altitude) | Experimental | Cycling at high altitude |
|
| Constant work-rate at altitude 470 m above sea level (low altitude) | Active Comparator | Cycling at low altitude |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High altitude exposure | Procedure | Exposure to 2500m of altitude |
|
| Measure | Description | Time Frame |
|---|---|---|
| cycle constant work-rate exercise test | Difference in cycle constant work-rate exercise test (CWRET) time at 2500 vs. 490 m (Time Frame 24 to 30 hours) | 30 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Heart rate | Difference in cardiorespiratory measurements: Heart rate, during a cycle constant work-rate exercise test (CWRET) time at high altitude vs. low altitude | 30 hours |
| Ventilation in liters per minute |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital of Zurich | Zurich | 8091 | Switzerland |
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| ID | Term |
|---|---|
| C535833 | Pulmonary edema of mountaineers |
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| Low altitude exposure | Procedure | Exposure to 490 m |
|
Difference in cardiorespiratory measurements: Ventilation assessed in liters per minute, during a cycle constant work-rate exercise test (CWRET) time at high altitude vs. low altitude
| 30 hours |
| Oxygen uptake | Difference in cardiorespiratory measurements: oxygen uptake, during a cycle constant work-rate exercise test (CWRET) time at high altitude vs. low altitude | 30 hours |
| Oxygen saturation | Difference in cardiorespiratory measurements: Oxygen saturation, during a cycle constant work-rate exercise test (CWRET) time at high altitude vs. low altitude | 30 hours |
| Partial pressure or oxygen | Difference in partial pressure of oxygen at the beginning and end of a cycle constant work-rate exercise test (CWRET) time at high altitude vs. low altitude | 30 hours |
| Tricuspid pressure gradient | Trans-tricuspid pressure gradient by echocardiography | 30 hours |
| Borg dyspnoea scale | Difference in post-exercise Borg dyspnoea and leg fatigue scale during a cycle constant work-rate exercise test (CWRET) time at high altitude vs. low altitude | 30 hours |
| Visual analogue scale | Difference in baseline in symptoms assessed by the Visual Analogue Scale at high altitude vs. low altitude | 30 hours |
| sit-to-stand test frequency | Difference in baseline in sit-to-stand test frequency of standing up from a chair in a minute at high altitude vs. low altitude | 30 hours |
| 6 minute walk test | Difference in baseline in 6 minute walk test distance at high altitude vs. low altitude | 30 hours |