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Randomized crossover Trial in patients with Pulmonary Hypertension (PAH, CTEPH) to assess the acute response to High Altitude (2500m above sea level) in constant loaded exercise capacity.
Low altitude baseline measurements will be performed in Zurich (460m asl) including Echocardiography, Right heart catheterization, 6MWT, pulmonary function test, clinical assessment and blood gas Analysis.
Randomly assigned to the order of testing, the participants will be tested in Low Altitude (Zurich, 470m) and at High Altitude (2500m).
Towards the end of the exposure after approximately 4 hours, the participants will perform a constant loaded exercise test on an Ergometer with a calculated resistance of their 60% max Workload.
The patients will be encouraged to perform these tests up to their physical exhaustion.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Order A | Experimental | Firstly, the participants will have their assessments at low altitude (Low altitude: 470m above sea level) in Zurich and consecutively the exposure to High Altitude (Säntis; 2500m above sea Level). |
|
| Order B | Experimental | Firstly, the participants will exposed to High Altitude (Säntis; 2500m above sea level) and consecutively will they have assessement in Zurich (Low altitude; 470m above sea level). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Assessment at Low Altitude (470m above sea level) | Other | Assessment at Low Altitude (in Zurich; 470m above sea level) in order to compare this data with High altitude exposure |
|
| Measure | Description | Time Frame |
|---|---|---|
| endurance time at High Altitude | The time of a constant loaded exercise test by an ergometer in sitting position at High Altitude will be compared with the same test at low altitude (370m above sea level) | 1 day at altitude |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Silvia Ulrich, Prof. | University of Zurich | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Respiratory Clinic, University Hospital of Zurich | Zurich | 8091 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35628896 | Derived | Schneider SR, Lichtblau M, Furian M, Mayer LC, Berlier C, Muller J, Saxer S, Schwarz EI, Bloch KE, Ulrich S. Cardiorespiratory Adaptation to Short-Term Exposure to Altitude vs. Normobaric Hypoxia in Patients with Pulmonary Hypertension. J Clin Med. 2022 May 14;11(10):2769. doi: 10.3390/jcm11102769. |
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| ID | Term |
|---|---|
| D006976 | Hypertension, Pulmonary |
| D000532 | Altitude Sickness |
| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D006973 | Hypertension |
| D014652 | Vascular Diseases |
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Including a baseline assessment and assessments at Low altitude and High altitude
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| Exposure to High Altitude (2500m above sea level) | Other | Exposure to High Altitude (Säntis; 2500m above sea level) for approximately 5 hours |
|
| D002318 |
| Cardiovascular Diseases |
| D012120 | Respiration Disorders |