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Randomized crossover Trial in patients with Pulmonary Hypertension (PAH, CTEPH) to assess the acute response to High Altitude (2500m above sea level) in altitude related symptoms
Low altitude baseline measurements will be performed in Zurich (460m asl) including Echocardiography, Right heart catheterization, 6MWT, pulmonary function test, clinical assessment and blood gas Analysis.
Randomly assigned to the order of testing, the participants will be tested at Low Altitude (Zurich, 470m) and High Altitude (2500m).
Regularly during the exposure of approximately 5 hours, the participants will be asked to complete altitude related symptom questionnaires
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Order A | Experimental | The participants will be tested in the following order: Zurich (Low altitude: 470m above sea level) and consecutively High Altitude (Säntis; 2500m above sea Level) |
|
| Order B | Experimental | The participants will be tested at High Altitude (Säntis; 2500m above sea level) and consecutively in Zurich (Low altitude; 470m above sea level). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Assessment at Low Altitude (470m above sea level) | Other | Assessment at Low Altitude (in Zurich; 470m above sea level) in order to compare this data with High altitude exposure |
|
| Measure | Description | Time Frame |
|---|---|---|
| Altitude related symptoms at High Altitude | Completion of altitude related questionnaires during the exposure to the Elevation of 2500m above sea level | 5 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Silvia Ulrich, Prof. | University of Zurich | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Respiratory Clinic, University Hospital of Zurich | Zurich | 8091 | Switzerland |
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| ID | Term |
|---|---|
| D006976 | Hypertension, Pulmonary |
| D000532 | Altitude Sickness |
| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D006973 | Hypertension |
| D014652 | Vascular Diseases |
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Including a baseline assessment and assessments at Low altitude and High altitude
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| Exposure to High Altitude (2500m above sea level) | Other | Exposure to High Altitude (Säntis; 2500m above sea level) for approximately 5 hours |
|
| D002318 |
| Cardiovascular Diseases |
| D012120 | Respiration Disorders |