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Healthy young adults will complete three trials in a randomized crossover counter-balanced order, including two different loads of resistance exercise and sedentary control. During each trial, blood samples will be collected.
The investigators hypothesized that high-load and low-load resistance exercise exert similar metabolic responses.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High-load resistance exercise | Experimental | 4 high-load resistance exercises that target all major muscle groups. |
|
| Low-load resistance exercise | Experimental | 4 low-load resistance exercises that target all major muscle groups. |
|
| Sedentary control | No Intervention | Subjects in control trial stayed sedentary during the period. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High-load resistance exercise | Other | Subjects in high-load trial performed 4 sets per exercise, 8 repetitions with load of 85%-8RM with 90 sec of rest between sets. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes in glucose | glucose in mg/dL | 4-hour during each study intervention |
| Changes in insulin | insulin in mU/L | 4-hour during each study intervention |
| Changes in TG | TG mg/dL | 4-hour during each study intervention |
| Changes in uric acid | uric acid mg/dL. | 4-hour during each study intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in biomarkers of inflammation | Biomarkers of inflammation will be measured such as IL-10 in pg/mL and IL-6 in pg/mL. | 4-hour during each study intervention |
| Changes in cortisol | cortisol in ng/mL |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hung-Wen Liu, Ph.D. | National Taiwan Normal University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Taiwan Normal University | Taipei | 162 | Taiwan |
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| Low-load resistance exercise | Other | Subjects in low-load trial performed 4 sets per exercise, 15 repetitions with load of 45%-8RM with 90 sec of rest between sets. |
|
| 4-hour during each study intervention |
| Changes in lactate | lactate in mmol/L | 4-hour during each study intervention |
| Changes in complete blood count | blood cell count in count per µL | 4-hour during each study intervention |
| Borgs Ratings of Perceived Exertion (RPE) | Borgs RPE is a method of estimating exertion rating, based on a 6 to 20 rating scale (6 being the no exertion at all, 20 being maximal exertion). | 1-hour during each exercise intervention |
| Changes in ET-1 | ET-1 in pg/mL | 4-hour during each study intervention |
| Changes in NO | NO in µmol/L | 4-hour during each study intervention |
| Changes in biomarkers of muscle damage | Biomarkers of muscle damage will be measured such as CK in U/L and LDH in U/L. | 4-hour during each study intervention |
| Heart rate (HR) | HR will be measured during each study intervention. | 6-hour during each study intervention |
| Visual Analogue Scale (VAS) of appetite | Hunger, fullness, desire to eat, and prospective food consumption will be measured via VAS ratings, based on a 100 mm long scale (0 being "not at all", 100 being "extremely"). | 6-hour during each study intervention |
| Changes in biomarkers of appetite | Biomarkers of appetite will be measured such as ghrelin in pg/mL and PYY in pg/mL. | 4-hour during each study intervention |