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Healthy young and older adults will complete two trials in a randomized crossover counter-balanced order, including resistance exercise and sedentary control. During each trial, blood samples will be collected.
The investigators hypothesized that an acute bout of resistance exercise exert different inflammation responses in young and older adults.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High-load resistance exercise | Experimental | Subjects in high-load trial performed 3 sets per exercise, 8 repetitions with load of 70%-1RM with 90 sec of rest between sets, followed by a fourth set to voluntary failure. |
|
| Sedentary control | No Intervention | Subjects in control trial stayed sedentary during the period. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Resistance exercise | Other | 4 total resistance exercises that target all major muscle groups. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes in biomarkers of inflammation | Biomarkers of inflammation will be measured such as IL-10 in pg/mL, IL-6 in pg/mL, TNF-α in pg/mL. | 24-hour during each study intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in glucose | glucose in mg/dL | 24-hour during each study intervention |
| Changes in metabolic parameters | Metabolic parameters will be measured such as TC in mg/dL, TG in mg/dL, and HDL in mg/dL. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hung-Wen Liu, Ph.D. | National Taiwan Normal University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Taiwan Normal University | Taipei | 162 | Taiwan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39475859 | Derived | Tsai SH, Cheng HC, Little JP, Islam H, Liu HW. Elevated Plasma IL-6 Coincides with Activation of STAT3 in PBMC After Acute Resistance Exercise. Med Sci Sports Exerc. 2024 Nov 1;56(11):2117-2124. doi: 10.1249/MSS.0000000000003503. |
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| ID | Term |
|---|---|
| D055070 | Resistance Training |
| ID | Term |
|---|---|
| D005081 | Exercise Therapy |
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
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| 24-hour during each study intervention |
| Changes in biomarkers of muscle damage | Biomarkers of muscle damage will be measured such as CK in U/L and LDH in U/L. | 24-hour during each study intervention |
| Changes in molecular markers in peripheral blood mononuclear cells (PBMC) | Molecular markers in PBMC will be measured such as STAT3 in arbitrary units, IKK in arbitrary units, IkB in arbitrary units, p65 in arbitrary units, SOCS3 in arbitrary units, AMPK in arbitrary units, and SIRT1 in arbitrary units. | 24-hour during each study intervention |
| Changes in complete blood count (CBC) | The white blood cell count and the count of each white blood cell type will be measured. | 24-hour during each study intervention |
| Borgs Ratings of Perceived Exertion (RPE) | Borgs RPE is a method of estimating exertion rating, based on a 6 to 20 rating scale (6 being the no exertion at all, 20 being maximal exertion). | 1-hour during each exercise intervention |
| D005791 |
| Patient Care |
| D013812 | Therapeutics |
| D026741 | Physical Therapy Modalities |
| D064797 | Physical Conditioning, Human |
| D015444 | Exercise |
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |