Oral and Systemic aMMP-8 in Periodontal Disease

Local And Systemic Levels of aMMP-8 in Gingivitis and Stage 3 Periodontitis

Periodontal disease is an inflammatory process that can result in tooth loss and also is considered a modifying factor for systemic health. Matrix metalloproteinase (MMP)-8 is the major collagenase of periodontal tissue breakdown. The aim of the present study is to analyze active (aMMP-8) levels in gingival crevicular fluid (GCF), saliva and serum in the context of new criteria of gingivitis and stage 3 grade C periodontitis.

Inclusion Criteria:

• systemically healthy and non-smoker individuals aged 25 to 50 years
• having ≥20 teeth present (except third molars)
• individuals with periodontally healthy, gingivitis and stage 3 periodontitis diagnoses

Exclusion Criteria:

• having any systemic disease
• smoking
• pregnancy or lactation
• using antibiotic or any anti-inflammatory drug or any periodontal treatment within the past 6 months.