Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The aim of this study to evaluate the diagnostic accuracy of a new qualitative aMMP-8 POC test in different periodontal health and disease and as compared to the established quantitative laboratory method (ELISA)
MMP-8 has been reported to reflect the inflammatory status in periodontal tissues and, therefore represent as potential biomarkers of periodontitis. A positive aMMP-8 test could be an early indicator of these excessive and undesired tissue reactions.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Chronic periodontitis | This groups participant has radiographically moderate alveolar bone loss, CAL > 5 mm and PD >6 mm in several sites of each quadrant |
| |
| Generalized aggressive periodontitis | This demonstrated a generalized pattern of severe breakdown and CAL > 5 mm and PD > 6 mm on 8 > teeth; minimum three of those were other than first incisors or first molars |
| |
| Gingivitis | This group has varying degrees of gingival inflammation, with CAL < 2 mm, without any radiographical bone loss due to periodontitis |
| |
| Implant | Implants classified PD < 5 mm, no bleeding on probing, no suppuration and no radiographic bone loss > 0.5 mm |
| |
| Health | Probing depth (PD) < 3mm, no gingival recession due to periodontal disease, and clinical attachment level (CAL) < 2 mm, BOP in < 10% of full-mouth score examination |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| GCF collection with aMMP-8 chair side test | Diagnostic Test |
|
| Measure | Description | Time Frame |
|---|---|---|
| aMMP-8 levels of GCF | GCF levels measured by IFMA | 2 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Salivary MMP-8 levels | Saliva levels measured by IFMA | 2 hours |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
All participants have minimum 20 teeth
Not provided
| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| D010520 | Aggressive Periodontitis |
| D055113 | Chronic Periodontitis |
| ID | Term |
|---|---|
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D010518 | Periodontitis |
| D002908 | Chronic Disease |
Not provided
Not provided
Not provided
Not provided
Not provided
|
| Saliva collection | Other |
|
| D020969 |
| Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |