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The aim of this clinical study was to determine the levels of ferritin, alkaline phosphatase and matrix metalloproteinase-8 in the gingival crevicular fluid (GCF) and saliva samples were collected from 60 systemically healthy, non-smoker periodontitis (P group, n = 20), gingivitis (G group, n = 20) and periodontally healthy individuals (S group, n = 20) and all clinical parameters were recorded for all groups at baseline. GCF and serum samplings and clinical records were also repeated at 1st and 3rd months visitsfor only P group. Ferritin, MMP8, and ALP levels in samples were determined by enzyme-linked immunosorbent assay (ELISA).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| periodontally healthy | Experimental | Full-mouth clinical periodontal measurements recorded and GCF and saliva obtained. |
|
| gingivitis | Experimental | Full-mouth clinical periodontal measurements recorded and GCF and saliva obtained. |
|
| periodontitis | Experimental | Full-mouth clinical periodontal measurements recorded and GCF and saliva obtained. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| GCF and saliva obtaining | Diagnostic Test | The patient was asked to sit upright and tilt his/her head forward to collect saliva samples. İn this way, unstimulated saliva was allowed to accumulate in the floor of the mouth. The accumulated saliva was collected in a sterile container. It was then transferred to a propylene tube. The tubes were centrifuged and the clear part at the top of the tube was taken with a sterile syringe and transferred to a different propylene tube with 0.5 ml in each tube. Also, 4 samples of gingival crevicular fluid, 1 from each quadrant of the patient's jaw, were collected by means of paper strips and put into propylene tube. Tubes were stored at -80ºC until the day of analysis. |
| Measure | Description | Time Frame |
|---|---|---|
| The total amount of Ferritin in GCF and saliva | 24 hours after taking the clinical measurements at the first visit | |
| The total amount of ALP in GCF and saliva | 24 hours after taking the clinical measurements at the first visit |
| Measure | Description | Time Frame |
|---|---|---|
| The total amount of MMP-8 in GCF and saliva | 24 hours after taking the clinical measurements at the first visit |
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Inclusion Criteria:
Systemically healthy
At least twenty permanent teeth in the mouth
Non-smoker
No medication for continuous use
Those who have not used antibiotics, anti-inflammatory and systemic corticosteroid drugs in the last 6 months.
Not in pregnancy or lactation period.
For the periodontitis group that has not received periodontal treatment in the last 6 months
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Izmir Katip Çelebi University Department of Periodontology | Izmir | Çiğli | 35640 | Turkey (Türkiye) |
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| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| ID | Term |
|---|---|
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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