The Pathogenesis of Human Senile Cataract

The Pathogenesis of Age-related Cataract

To study the pathological mechanism of cataract by genomics, transcriptomics, and proteomics.

Tissue samples and aqueous humor samples will be collected from each individual patients by cataract surgery. After sample treatment, different techniques will be applied for analysis. And bioinformatics approach is applied for data treatment and analysis.The data of genomics, transcriptomics, and proteomics will be analyzed for study of pathological mechanism of cataract.

Inclusion Criteria:

• Patients with the explicit diagnosis of cataract (including senile cataract, congenital cataract, complicated cataract, metabolic cataract, traumatic cataract, etc.) in the operated eye are willing to undergo cataract surgery.

Exclusion Criteria:

• Patients whose cataracts need not be operated
• Patients with any contraindications to cataract surgery
• Patients are unwilling to undergo cataract surgery