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This retrospective-prospective bidirectional cohort study aims to observe ocular parameter changes, different surgical/vision recovery strategies and postoperative adverse effects among young children with cataract. The influence on psychology and cognitive function will be taken into consideration as well.
Pediatric cataract, one of the leading causes of childhood blindness globally, is complex and of great difficulty in treatment. Pediatric patients with cataract (congenital, traumatic or complicated) are enrolled. In this study, investigators will compare ocular parameter changes, different surgical/vision timing or recovery strategies and adverse effects among young children （age < 18 yo）before and after cataract surgery. The influence on psychology and cognitive function will be taken into consideration as well. The whole blood samples of participants and parents are collected and retained in our biobank for gene sequencing, hoping to explore the genetic factors in association with pathogenesis. For children received cataract surgery, samples of partial anterior capsular tissue and 1 ml aqueous humor were collected during operation for further analysis. Multimodal artificial intelligence analyses are performed to establish accurate diagnosis/treatment scheme and disease prediction model.
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| Measure | Description | Time Frame |
|---|---|---|
| Best-corrected visual acuity changes | Best-corrected visual acuity changes are measured by visual acuity charts (Teller/Lea symbol/ETDRS chart) every 1 year at scheduled time | Baseline and through study completion, an average of 1 year |
| Intraocular pressure changes | Intraocular pressures are measured by NCT machine | Baseline and through study completion, an average of 1 year |
| Refractive power changes | Refractive power are measured at baseline and every visit at least every 1 year | Baseline and through study completion, an average of 1 year |
| Ocular biological measurements changes | Ocular biological measurements including axial length, corneal keratometry, anterior chamber angle/depth, corneal endothelial cell number and appearance | Baseline and through study completion, an average of 1 year |
| Incidence changes of postoperative complications | Incidence of postoperative complications, such as glaucoma-related adverse, myopic shift, strabismus and anisometropia and so on | Baseline and through study completion, an average of 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Other factors changes | Sleep, depression, cognitive function are measured by questionnaires. Self-Rating Scale of Sleep: minimum value-1 point, maximum value-50, and higher scores mean worse outcome. Hamilton Depression Scale: <7 points-normal, and higher scores mean worse outcome. Loewenstein Cognitive Assessment: for every question, minimum 1 point, and maximum 4 points. Higher scores mean worse outcomes. |
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Inclusion Criteria:
Exclusion Criteria:
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This is a retrospective-prospective bidirectional cohort study. Patients aged < 18 yo at the 1st visit are enrolled.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Zhenzhen Liu, PhD | Contact | +020 66618932 | liuzhenzhen@gzzoc.com |
| Name | Affiliation | Role |
|---|---|---|
| Yizhi Liu, PhD | Zhongshan Ophthalmic Center, Sun Yat-sen University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Zhongshan Ophthalmic Center | Recruiting | Guangzhou | Guangdong | 510060 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28465303 | Background | Solebo AL, Teoh L, Rahi J. Epidemiology of blindness in children. Arch Dis Child. 2017 Sep;102(9):853-857. doi: 10.1136/archdischild-2016-310532. Epub 2017 May 2. | |
| 17003414 | Background | Chak M, Wade A, Rahi JS; British Congenital Cataract Interest Group. Long-term visual acuity and its predictors after surgery for congenital cataract: findings of the British congenital cataract study. Invest Ophthalmol Vis Sci. 2006 Oct;47(10):4262-9. doi: 10.1167/iovs.05-1160. |
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| ID | Term |
|---|---|
| D058442 | Capsule Opacification |
| ID | Term |
|---|---|
| D002386 | Cataract |
| D007905 | Lens Diseases |
| D005128 | Eye Diseases |
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The whole blood samples of participants and parents are collected and retained in our biobank for gene sequencing, hoping to explore the genetic factors in association with pathogenesis.
| Baseline and through study completion, an average of 1 year |
| BMI changes | BMI is measured by technicians in every visit | Baseline and through study completion, an average of 1 year |
| Blood pressure changes | Diastolic and systolic blood pressure are measured by technicians in every visit | Baseline and through study completion, an average of 1 year |
| Stereopsis changes | Stereopsis is measured by Randot Stereotest | Baseline and through study completion, an average of 1 year |
| Optical coherence tomography (OCT) changes | Retinal thickness is measured and analyzed by OCT | Baseline and through study completion, an average of 1 year |
| 28539328 | Background | Long E, Zhang X, Liu Z, Wu X, Tan X, Lin D, Cao Q, Chen J, Lin Z, Wang D, Li X, Li J, Wang J, Li W, Lin H, Chen W, Liu Y. Dynamic response to initial stage blindness in visual system development. Clin Sci (Lond). 2017 Jun 28;131(13):1515-1527. doi: 10.1042/CS20170234. Print 2017 Jul 1. |