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| Name | Class |
|---|---|
| Eye & ENT Hospital of Fudan University | OTHER |
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The purpose of this study is to evaluate the long-term visual outcome of the cataract surgery using a large-scale and comprehensive database of pediatric cataract participants, including congenital and traumatic cataract. The investigators will further investigate into the various genetic and environmental factors that may contribute to the pathogenesis of pediatric cataract.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Congenital cataract group | Cataract patients diagnosed with congenital cataract. |
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| Traumatic cataract group | Cataract patients diagnosed with traumatic cataract. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| intraocular lens implantation | Procedure | 1）Pediatric cataract patients with intraocular lens implantation and those without intraocular lens implantation；2）Traumatic cataract patients with intraocular lens implantation and those without intraocular lens implantation |
| Measure | Description | Time Frame |
|---|---|---|
| Differences in the visual outcomes of pediatric cataract patients. | Visual outcomes are evaluated including visual acuity with or without correction, refractive changes, intraocular pressure, fundus function, fixation type, vision development, growth of axial length, contrast sensitivity and other visual outcome measurements. | Follow-up until ten years after surgery. |
| Genetic diversity based on biospecimen samples of pediatric cataract patients. | Sequencing of genes (including exons, promoters, 5' UTR and 3' UTR sequences) on a large scale to intensively investigate into the sites and functions of single nucleotide polymorphism (SNP) correlated with clinical features of congenital cataract patients, compared to traumatic cataract patients.Samples of blood, aqueous humor, anterior capsular membranes and lens tissues were applied for the genetic analysis. | Analyzed within six months after surgery. |
| Measure | Description | Time Frame |
|---|---|---|
| Differences in the clinical phenotypes of pediatric cataract patients. | Cataract type and severity of ametropic cataract patients are evaluated and images are captured before receiving the cataract surgery. | Evaluated before receiving the cataract surgery. |
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Inclusion Criteria:
Exclusion Criteria:
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Medical centre: Eye and ENT Hospital of Fudan University
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yi Lu, M.D. | Contact | +86-02164377134 | luyieent@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Yi Lu, M.D. | Eye and ENT Hospital of Fudan University | Study Chair |
| Xiangjia Zhu, M.D. | Eye and ENT Hospital of Fudan University | Study Director |
| Keke Zhang, M.D. |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Eye and ENT Hospital of Fudan University | Recruiting | Shanghai | Shanghai Municipality | 200031 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31246115 | Derived | Zhu X, He W, Du Y, Kraus CL, Xu Q, Sun T, Yu J, Lu Y. Presence of Posterior Staphyloma in Congenital Cataract Children. Curr Eye Res. 2019 Dec;44(12):1319-1324. doi: 10.1080/02713683.2019.1637437. Epub 2019 Jul 5. |
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| ID | Term |
|---|---|
| D020132 | Anticipation, Genetic |
| ID | Term |
|---|---|
| D020022 | Genetic Predisposition to Disease |
| D004198 | Disease Susceptibility |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
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| ID | Term |
|---|---|
| D019654 | Lens Implantation, Intraocular |
| ID | Term |
|---|---|
| D054140 | Refractive Surgical Procedures |
| D013508 | Ophthalmologic Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
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Samples of blood, aqueous humor, anterior capsular membranes and lens tissues from pediatric cataract patients.
| Eye and ENT Hospital of Fudan University |
| Principal Investigator |
| Wenwen He, M.D. | Eye and ENT Hospital of Fudan University | Principal Investigator |
| Yu Du, M.D. | Eye and ENT Hospital of Fudan University | Principal Investigator |
| Yinglei Zhang, M.D. | Eye and ENT Hospital of Fudan University | Principal Investigator |
| Ruiqi Chang, M.D. | Eye and ENT Hospital of Fudan University | Principal Investigator |
| D013568 | Pathological Conditions, Signs and Symptoms |