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| Name | Class |
|---|---|
| Eye & ENT Hospital of Fudan University | OTHER |
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The purpose of this study is to evaluate the long-term visual outcome of the cataract surgery using a large-scale and comprehensive database of high myopic cataract and age-related cataract patients. The investigators will further investigate into the various genetic and environmental factors that may contribute to the pathogenesis of high myopic cataract.
High myopic cataract (HMC) has become a major high-risky type of cataract in China, which accounts for nearly 30% of cataract in recent years. Compared to age-related cataract, HMC is characterized with earlier onset, severer lens opacities, higher incidence of vitreoretinopathy and postoperative complications compared to age-related cataract(ARC).
The main purpose of this study is to evaluate the long-term visual outcome of the cataract surgery using a large-scale and comprehensive database of high myopic cataract, when compared to those age-matched ARC patients.
On the other hand, due to the lack of research in the pathogenesis of HMC, it is difficult for the investigators to precisely evaluate its risk and prognosis, and to improve its prevention and treatment. The previous study of investigators majored in a large-sample analysis on the clinical features and related genes of HMC. After preliminary screening, eight genes were selected for further investigation: 1) genes related to pathogenesis of HMC: CRYAA/ GSTP1/ TXNRD2;2) genes related to vitreoretinopathy: MCP1/ VEGFA/ CFH; 3) genes related to postoperative complications: TGFB2/ CERS2. In the present study, in order to establish a risk model of HMC from the aspect of precision medicine, the investigators are preparing to set up a comprehensive clinical database for further sequencing of selected genes (including exons, promoters, 5' UTR and 3' UTR sequences) on a large scale, to intensively investigate into the sites and functions of single nucleotide polymorphism (SNP) correlated with clinical features of HMC.
The research aim to evaluate the long-term visual outcome of the cataract surgery using a large-scale and comprehensive database of high myopic cataract, to thoroughly illustrate the influence of HMC-related genes to its prognosis and to elucidate the pathogenesis of HMC, for further promotion in the disease prevention and prognosis as well.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High myopic cataract group | Cataract patients with high myopia. |
| |
| Age-related cataract group | Age-related cataract patients. |
| |
| Ametropic cataract group | Cataract patients with ametropia. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cataract | Other | The genetic and environmental factors concerning to the pathogenesis of cataract in the three groups. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Differences in the clinical phenotypes and visual outcomes of high myopic cataract patients | Cataract type and severity of high myopic cataract patients are evaluated using LOCSIII grading system. Visual outcomes are also evaluated including visual acuity with or without correction, intraocular pressure, fundus function, contrast sensitivity and other visual outcome measurements. | Follow-up until five years after surgery |
| Differences in the clinical phenotypes and visual outcomes of age-related cataract patients | Cataract type and severity of age-related cataract patients are evaluated using LOCSIII grading system. Visual outcomes are also evaluated including visual acuity with or without correction, intraocular pressure, fundus function, contrast sensitivity and other visual outcome measurements. | Follow-up until five years after surgery |
| Differences in the clinical phenotypes and visual outcomes of ametropic cataract patients | Cataract type and severity of ametropic cataract patients are evaluated using LOCSIII grading system. Visual outcomes are also evaluated including visual acuity with or without correction, intraocular pressure, fundus function, contrast sensitivity and other visual outcome measurements. | Follow-up until five years after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Genetic diversity based on biological specimen samples of three groups | Sequencing of selected genes (including exons, promoters, 5' UTR and 3' UTR sequences) on a large scale to intensively investigate into the sites and functions of single nucleotide polymorphism (SNP) correlated with clinical features of HMC, compared to age-related cataract and ametropic cataract patients. | Analyzed within six months after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Difference in the surgical procedure of three groups | To compare the difference in the surgical procedure of three groups. | Recorded on the surgery day for further analysis |
| Difference in the Diagnostic test of three groups |
Inclusion Criteria:
Exclusion Criteria:
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Cataract patients who will undergo cataract surgery in Eye and ENT Hospital of Fudan University.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yi Lu, M.D. | Contact | (86)021-64377134 | luyieent@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Yi Lu, M.D. | Eye and ENT Hospital of Fudan University | Study Chair |
| Xiangjia Zhu, M.D. | Eye and ENT Hospital of Fudan University | Study Director |
| Keke Zhang, M.D. |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Eye and ENT Hospital of Fudan University | Recruiting | Shanghai | Shanghai Municipality | 200031 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40061825 | Derived | Zhang Y, Zhang S, Zhang K, Lu Y, Zhu X. Characteristics of the Corneal Endothelium in Elderly Adults with High Myopia. Phenomics. 2025 Jan 27;4(6):562-569. doi: 10.1007/s43657-024-00186-6. eCollection 2024 Dec. | |
| 39313860 | Derived | Hu X, Qi J, Cheng K, He W, Zhang K, Zhao C, Lu Y, Zhu X. Effectiveness of prophylactic capsular tension ring implantation during cataract surgery in highly myopic eyes. J Cataract Refract Surg. 2024 Oct 1;50(10):1030-1036. doi: 10.1097/j.jcrs.0000000000001495. |
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Undecided.
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| ID | Term |
|---|---|
| D002386 | Cataract |
| D020132 | Anticipation, Genetic |
| ID | Term |
|---|---|
| D007905 | Lens Diseases |
| D005128 | Eye Diseases |
| D020022 | Genetic Predisposition to Disease |
| D004198 | Disease Susceptibility |
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| ID | Term |
|---|---|
| D002387 | Cataract Extraction |
| ID | Term |
|---|---|
| D054140 | Refractive Surgical Procedures |
| D013508 | Ophthalmologic Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
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Blood samples from HMC, ARC and anisometropia patients collected before the cataract surgery. Aqueous humor and capsular membranes samples from HMC, ARC and ametropic cataract patients collected during the cataract surgery.
To compare the difference in the diagnostic test of three groups.
| Recorded before the surgery day for further analysis |
| Difference in the complications of the cataract surgery of three groups | To compare the prevalence of complications of the cataract surgery in HMC,ARC and ametropic cataract patients. | Follow-up until five years after surgery |
| Eye and ENT Hospital of Fudan University |
| Principal Investigator |
| Wenwen He, M.D. | Eye and ENT Hospital of Fudan University | Principal Investigator |
| Yu Du, B.S. | Eye and ENT Hospital of Fudan University | Principal Investigator |
| Yinglei Zhang, M.D. | Eye and ENT Hospital of Fudan University | Principal Investigator |
| Zhennan Zhao, Ph.D. | Eye and ENT Hospital of Fudan University | Principal Investigator |
| Ruiqi Chang, B.S. | Eye and ENT Hospital of Fudan University | Principal Investigator |
| 37178442 | Derived | He W, Wei L, Liu S, Huang Z, Qi J, Zhang K, Meng J, Du Y, Lu Y, Zhu X. Role of Optic Nerve Head Characteristics in Predicting Intraocular Pressure Spikes after Cataract Surgery in Highly Myopic Eyes. Ophthalmol Ther. 2023 Aug;12(4):2023-2033. doi: 10.1007/s40123-023-00714-z. Epub 2023 May 13. |
| 37138195 | Derived | He W, Cheng K, Zhao L, Liu S, Huang Z, Zhang K, Du Y, Zhou X, Lu Y, Zhu X. Long-Term Outcomes of Posterior Capsular Opacification in Highly Myopic Eyes and Its Influencing Factors. Ophthalmol Ther. 2023 Aug;12(4):1881-1891. doi: 10.1007/s40123-023-00711-2. Epub 2023 May 3. |
| 36977327 | Derived | Meng J, Chen Y, Cheng K, Qi J, Du Y, Yao Y, He W, Zhang K, Lu Y, Zhu X. LONG-TERM PROGRESSION PATTERN OF MYOPIC TRACTIONAL MACULOPATHY: Outcomes and Risk Factors. Retina. 2023 Jul 1;43(7):1189-1197. doi: 10.1097/IAE.0000000000003791. |
| 32161773 | Derived | Lu Q, He W, Qian D, Lu Y, Zhu X. Measurement of crystalline lens tilt in high myopic eyes before cataract surgery using swept-source optical coherence tomography. Eye Vis (Lond). 2020 Mar 6;7:14. doi: 10.1186/s40662-020-00176-5. eCollection 2020. |
| D020969 |
| Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |