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| Name | Class |
|---|---|
| Swedish Foundation for Strategic Research | OTHER |
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Aim of the study is to investigate health effects of oats and oat derived components, in human intervention studies, with the purpose to build new knowledge for development of cardiometabolic protective foods.
The overall goal is to increase the knowledge which can be used for the development of food products with anti-diabetic properties, with the purpose to facilitate healthier food choices for people. More specifically the primary purpose of this project is to evaluate effects in healthy humans on cardiometabolic test markers of oat and oat based product. The new knowledge will form a base for the development of oat based food products with added health values.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control product | Placebo Comparator | A glucose solution (glucose and water) based on 42 gram carbohydrates. |
|
| Oat Beverage 1 | Experimental | The test product is an oat based beverage with added vegetable oil. The test portion is based on 42 gram available carbohydrates and consumed as a breakfast meal prior to determinations of test variables in the morning. |
|
| Oat Beverage 2 | Experimental | The test product is an oat based beverage with added vegetable oil. The test portion is based on 42 gram available carbohydrates and consumed as a breakfast meal prior to determinations of test variables in the morning. |
|
| Oat Beverage 3 | Experimental | The test product is an oat based beverage with added vegetable oil. The test portion is based on 42 gram available carbohydrates and consumed as a breakfast meal prior to determinations of test variables in the morning. |
|
| Oat Beverage 4 | Experimental | The test product is an oat based beverage. The test portion is based on 42 gram available carbohydrates and consumed as a breakfast meal prior to determinations of test variables in the morning. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Oat Beverage 1 | Combination Product | Oat based beverage with added different concentration of extracted oat component. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Blood glucose regulation | Postprandial blood glucose regulation (incremental area under the curve) acute after intake of the test products and at forthcoming meals within 5.5 hours after consumption of test products. | 0 - 5.5 hours ( at fasting and then repeatedly after breakfast and Standardize lunch) |
| Measure | Description | Time Frame |
|---|---|---|
| Serum insulin | Acute effects of postprandial serum insulin concentrations (incremental area under the curve) after intake of the test products. | 0 - 5.5 hours ( at fasting and then repeatedly after breakfast and Standardize lunch) |
| plasma GLP-1 (glucagon-like peptide-1 ) |
| Measure | Description | Time Frame |
|---|---|---|
| Subjective appetite sensations | Determined with VAS (visual analogue scale) scales (0-100 mm) as a range of subjective sensations related to appetite (such as hunger, desire to eat or fullness) | 0 - 5.5 hours ( at fasting and then repeatedly after breakfast and Standardize lunch) |
| Breath hydrogen concentrations |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Anne Nilsson | Lund University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Food Technology, engineering and Nutrition, LTH, Lund University | Lund | 22100 | Sweden |
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| ID | Term |
|---|---|
| D035061 | Control Groups |
| ID | Term |
|---|---|
| D015340 | Epidemiologic Research Design |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D012107 | Research Design |
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a randomized blinded cross-over study
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| Oat Beverage 2 | Combination Product | Oat based beverage with added different concentration of extracted oat component. |
|
| Oat Beverage 3 | Combination Product | Oat based beverage with added different concentration of extracted oat component. |
|
| Oat Beverage 4 | Combination Product | Oat based beverage with added different concentration of extracted oat component. |
|
| Control product | Combination Product | Glucose based beverage without added test components is used as control product |
|
Gastro-intestinale hormones involved in appetite and metabolic regulation |
| 0 - 5.5 hours ( at fasting and then repeatedly after breakfast and Standardize lunch) |
| IL (interleukin)-6 | Inflammatory markers in blood | 0 - 5.5 hours ( at fasting and then repeatedly after breakfast and Standardize lunch) |
| Plasma PYY (peptide tyrosine tyrosine) | Gastro-intestinale hormones involved in appetite and metabolic regulation | 0 - 5.5 hours ( at fasting and then repeatedly after breakfast and Standardize lunch) |
| IL- 1beta | Inflammatory markers in blood | 0 - 5.5 hours ( at fasting and then repeatedly after breakfast and Standardize lunch) |
Indicator of gut fermentation |
| 0 - 5.5 hours ( at fasting and then repeatedly after breakfast and Standardize lunch) |
| Mood (valence and activity) | Determined with VAS (visual analogue scale) scales 0-100 mm | 0 - 5.5 hours ( at fasting and then repeatedly after breakfast and Standardize lunch) |
| D008722 | Methods |