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In this project we will investigate synergistic effects of oat polar lipids and beta glucans on postprandial glucose tolerance
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Placebo Comparator | White wheat flour bread |
|
| High betaglucans | Experimental | White wheat flour bread included beta glucans with the highest amounts in this study |
|
| Low beta glucans | Experimental | White wheat flour bread included beta glucans with the lowest amounts in this study |
|
| Low beta glucans + low polar lipids | Experimental | White wheat flour bread included a combination of the lowest amounts of beta glucans and polar lipids |
|
| low polar lipids | Experimental | White wheat flour bread included polar lipids |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High beta glucans | Other | higher dose betaglucans |
| |
| Low beta glucans |
| Measure | Description | Time Frame |
|---|---|---|
| Glucose tolerance | Postprandial glucose concentrations (mmol/L). The incremental area under the curve will be calculated and expressed as mmol*minutes/litre. | 3 hours. Fasting (time =0 minutes), 15 minutes, 30 minutes, 45 minutes, 60 minutes, 90 minutes, 120 minutes, 150 minutes, 180 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Subjective appetite variables | Postprandial sensation of hunger, satiety, and desire to eat will be determined with a 100 millimeter visual analogue scale (VAS). The left end of the VAS scale represent "not at all" (e.g. hungry) and right end of the scale represented "extremely". One scale for each parameter will be used. The total area under the curve will be calculated, and the results will be expressed as millimeter*minutes. |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Lund University, Food Technology, Engineering and Nutrition | Lund | 22100 | Sweden |
Will be available after request
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| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| D015799 | Gyrate Atrophy |
| D009765 | Obesity |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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Randomised food study in healthy subjects
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Four test products and one reference product (control). Participants are not aware of which product that is served at each visits
| Other |
lower dose beta glucans |
|
| Low beta glucans + low polar lipids | Other | low dose betaglucans in a combination with low dose of polar lipids |
|
| Polar lipids | Other | low dose polar lipids |
|
| Control | Other | No beta glucans or polar lipids |
|
| 3 hours. Fasting (time =0 minutes), 15 minutes, 30 minutes, 45 minutes, 60 minutes, 90 minutes, 120 minutes, 150 minutes, 180 minutes |
| D004700 | Endocrine System Diseases |
| D015785 | Eye Diseases, Hereditary |
| D005128 | Eye Diseases |
| D015862 | Choroid Diseases |
| D014603 | Uveal Diseases |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |