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| Name | Class |
|---|---|
| Swedish Foundation for Strategic Research | OTHER |
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Aim of the study is to investigate health effects of oats and oat derived components, in human intervention studies, with the purpose to build new knowledge for development of cardiometabolic protective foods.
The overall goal is to increase the knowledge which can be used for the development of food products with anti-diabetic properties, with the purpose to facilitate healthier food choices for people. More specifically the primary purpose of this project is to evaluate effects in healthy humans on cardiometabolic test markers of oat and oat based product. The new knowledge will form a base for the development of oat based food products with added health values.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Oat product 1 | Experimental | The test portion is based on 50 gram available carbohydrates with added vegetable oil A. Test portion consumed as a breakfast meal prior to determinations of test variables in the morning. |
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| Oat product 2 | Experimental | The test portion is based on 50 gram available carbohydrates with added vegetable oil B. Test portion consumed as a breakfast meal prior to determinations of test variables in the morning. |
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| Oat product 3 | Experimental | The test portion is based on 50 gram available carbohydrates with added vegetable oil C. Test portion consumed as a breakfast meal prior to determinations of test variables in the morning. |
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| Control Product | Placebo Comparator | The test portion is based on 50 gram available carbohydrates without added vegetable oil. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Effects of Oat and Oat Components on Cardiometabolic risk variables | Combination Product | Oat and oat bioactive components consumed as breakfast meal. |
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| Measure | Description | Time Frame |
|---|---|---|
| Blood glucose regulation | Postprandial blood glucose regulation (incremental area under the curve) acute after intake of the test products and at forthcoming meals within 5.5 hours after consumption of test products. | 0 - 5.5 hours ( at fasting and then repeatedly after breakfast and Standardize lunch) |
| Measure | Description | Time Frame |
|---|---|---|
| Serum insulin | Acute effects of postprandial serum insulin concentrations (incremental area under the curve) after intake of the test products. | 0 - 5.5 hours ( at fasting and then repeatedly after breakfast and Standardize lunch) |
| plasma GLP-1 (glucagon-like peptide-1 ) |
| Measure | Description | Time Frame |
|---|---|---|
| Subjective appetite sensations | Determined with VAS (visual analogue scale) scales (0-100 mm) as a range of subjective sensations related to appetite (such as hunger, desire to eat or fullness) | 0 - 5.5 hours ( at fasting and then repeatedly after breakfast and Standardize lunch) |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Anne Nilsson, PhD | Department of Food Technology, Engineering and Nutrition, Lund Univesity | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Food Technology, engineering and Nutrition, LTH, Lund University | Lund | 22100 | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39568724 | Derived | Hossain MM, Tovar J, Cloetens L, de Kam S, Nilsson A. Oat polar lipids and sunflower lecithin similarly improve cardiometabolic risk markers and appetite controlling hormone responses after breakfast and a subsequent lunch. A randomized crossover study in healthy adults. Front Nutr. 2024 Nov 6;11:1497844. doi: 10.3389/fnut.2024.1497844. eCollection 2024. |
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Gastro-intestinale hormones involved in appetite and metabolic regulation |
| 0 - 5.5 hours ( at fasting and then repeatedly after breakfast and Standardize lunch) |
| Serum triglycerides | Cardiometabolic risk markers | 0 - 5.5 hours ( at fasting and then repeatedly after breakfast and Standardize lunch) |
| Serum Free Fatty Acids | Cardiometabolic risk markers | 0 - 5.5 hours ( at fasting and then repeatedly after breakfast and Standardize lunch) |
| Plasma PYY (peptide tyrosine tyrosine) | Gastro-intestinale hormones involved in appetite and metabolic regulation | 0 - 5.5 hours ( at fasting and then repeatedly after breakfast and Standardize lunch) |