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| Name | Class |
|---|---|
| PepsiCo Global R&D | INDUSTRY |
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The objectives are to assess the effects of high viscosity vs. medium and low viscosity oat β-glucan on post-prandial glycemic response in healthy adult participants.
The trial will be a 3 week double-blinded, randomized, cross-over design with 3 treatment intervention (oatmeal breakfasts costain low, medium and high viscosity of beta glucan) periods separated by about 5-7 days washout period. Normoglycemic (<5.6 mmol/L) males and females (12 of each) of age 18-45 y with a body mass index (BMI) of 18.5-29.9 kg/m2 will be recruited.
Each participant will receive each of the following breakfast foods in a random order: 1) oat meal containing low viscosity beta glucan; 2) oat meal containing medium viscosity beta glucan; 3) oat meal containing high viscosity beta glucan. The participants will be asked to consume one of the breakfast foods during each visit.
Following each blood sample, appetite, physical comfort, energy/fatigue, and palatability of treatments will be measured by visual analogue scales (VAS).
Glucose measurements: Capillary blood will be collected during each visit by finger prick. Blood will be collected at fasting and at 15, 30, 45, 60, 90 and 120 minutes after the first bite/sip of the test product according to the Clinical Laboratory Standard Institute (CLSI) guidelines. Blood glucose will be measured in finger prick blood samples by glucose meters .
Males will be scheduled for three sessions over 3 weeks. Women will be scheduled during the first two weeks of their menstrual cycle (follicular phase), once per week.
During the wash-out days (5 - 7 days between each phase), participants can go about their daily activities unrestricted with the following exception: no strenuous activity or alcohol consumption on the days before the clinic visit. The investigators will ask that participants go to sleep at the same time on the days before the sessions.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Low Viscous | Experimental | Low Viscous Beta Glucan Oatmeal |
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| Medium Viscous | Experimental | Medium Viscous Beta Glucan Oatmeal |
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| High Viscous | Experimental | High Viscous Beta Glucan Oatmeal |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Oatmeal | Other |
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| Measure | Description | Time Frame |
|---|---|---|
| Blood Glucose | Total area under the curve (iAUC, mmol*min/L) for glucose | 0-200 mins |
| Measure | Description | Time Frame |
|---|---|---|
| Appetite (visual analogue scales) | Measured by VAS questionnaire at 12 time points used to calculate area under curve | 0-200 mins |
| Physical Comfort | Measured by VAS questionnaire at 12 time points used to calculate area under curve |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Peter Jones, PhD | University of Manitoba | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba | Winnipeg | Manitoba | R3T 6C5 | Canada |
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| 0-200 mins |
| Energy/Fatigue | Measured by VAS questionnaire at 12 time points used to calculate area under curve | 0-200mins |
| Palatability | Measured by VAS questionnaire at 12 time points used to calculate area under curve | at 5 mins |