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The objective of this study is to investigate the effect on postprandial glycaemia in a healthy population after intake of milk and oat based products.
Postprandial glycaemia, insulinaemia and GLP-1 will be measured after intake of test meals with equal amount of carbohydrates (adjusted using bread) and equal amount of total water.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Bread reference | Placebo Comparator | A standardized (50 grams carbohydrates) breakfast meal will be provided based on bread. |
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| Product 1: Milk | Experimental | A standardized (50 grams carbohydrates) breakfast meal will be provided based on bread and a test product based on milk. |
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| Product 2: Full fat milk + oat | Experimental | A standardized (50 grams carbohydrates) breakfast meal will be provided based on bread and a test product based on full fat milk and oat with high fiber content. |
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| Product 3: Skim milk + oat, high fibre | Experimental | A standardized (50 grams carbohydrates) breakfast meal will be provided based on bread and a test product based on skim milk and oat with high fiber content. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Bread reference | Other | Commercially available white wheat bread |
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| Measure | Description | Time Frame |
|---|---|---|
| Postprandial glycaemia capillary | Primary outcome is the difference in the two-hour incremental area under the curve (iAUC (0 - 120 min)) for capillary blood glucose between product 1-4 and the bread reference. | 0-120 min after consumption |
| Measure | Description | Time Frame |
|---|---|---|
| Postprandial glycaemia intravenous | The difference in the two-hour iAUC (0 - 120 min) for intravenous blood glucose between product 1-4 and the bread reference. | 0-120 min |
| Postprandial Cmax capillary glucose |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Aventure AB | Lund | Sweden |
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| Product 4: Skim milk + oat, low fibre | Experimental | A standardized (50 grams carbohydrates) breakfast meal will be provided based on bread and a test product based on skim milk and oat with low fiber content. |
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| Product 1: Milk | Other | Developed reference product based on milk |
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| Product 2: Full fat milk + oat | Other | Developed product based on full fat milk with addition of oat |
|
| Product 3: Skim milk + oat, high fibre | Other | Developed product based on skim milk with addition of oat giving a high fiber content to the product |
|
| Product 4: Skim milk + oat, low fibre | Other | Developed product based on skim milk with addition of oat giving a lower fiber content to the product |
|
The difference in the three-hour Cmax (0 - 180 min) of capillary blood glucose between product 1-4 and the bread reference.
| 0-180 min |
| Postprandial Cmax venous glucose | The difference in the three-hour Cmax (0 - 180 min) of intravenous blood glucose between product 1-4 and the bread reference. | 0-180 min |
| Postprandial glycaemia capillary | The difference in the three-hour iAUC (0 - 180 min) of capillary blood glucose between product 1-4 and the bread reference. | 0-180 min |
| Postprandial glycaemia venous | The difference in the three-hour iAUC (0 - 180 min) of intravenous blood glucose between product 1-4 and the bread reference. | 0-180 min |
| Postprandial glycaemia capillary | The difference in the one-hour iAUC (0 - 60 min) of capillary blood glucose between product 1-4 and the bread reference. | 0-60 min |
| Postprandial glycaemia venous | The difference in the one-hour iAUC (0 - 60 min) of intravenous blood glucose between product 1-4 and the bread reference. | 0-60 min |
| Postprandial glycaemia Tmax capillary | The difference in the Tmax (the time to maximum concentration) of capillary blood glucose between product 1-4 and the bread reference. | 0-180 min |
| Postprandial glycaemia Tmax venous | The difference in the Tmax of intravenous blood glucose between product 1-4 and the bread reference. | 0-180 min |
| Postprandial insulinaemia | The difference in the three-hour iAUC (0 - 180 min) of intravenous blood insulin between product 1-4 and the bread reference. | 0-180 min |
| Postprandial insulinaemia | The difference in the two-hour iAUC (0 - 120 min) of intravenous blood insulin between product 1-4 and the bread reference. | 0-120 min |
| Postprandial insulinaemia | The difference in the one-hour iAUC (0 - 60 min) of intravenous blood insulin between product 1-4 and the bread reference. | 0-60 min |
| Postprandial insulinaemia Cmax | The difference in the three-hour Cmax (0 - 180 min) of intravenous blood insulin between product 1-4 and the bread reference. | 0-180 min |
| Postprandial insulinaemia Tmax | The difference in the Tmax of intravenous blood insulin between product 1-4 and the bread reference. | 0-180 min |
| Postprandial GLP-1 bread reference | The difference in the one-hour iAUC (0 - 60 min) of intravenous blood GLP-1 between product 1-4 and the bread reference. | 0-60 min |
| Postprandial GLP-1, yoghurt control | The difference in the one-hour iAUC (0 - 60 min) of intravenous blood GLP-1 between products 2-4 and product 1. | 0-60 min |
| Postprandial GLP-1 Cmax bread reference | The difference in the one-hour Cmax (0 - 60 min) of intravenous blood GLP-1 between product 1-4 and the bread reference. | 0-60 min |
| Postprandial GLP-1 Cmax yoghurt control | The difference in the one-hour Cmax (0 - 60 min) of intravenous blood GLP-1 between products 2-4 and product 1. | 0-60 min |
| ID | Term |
|---|---|
| D009953 | Ornithine-Oxo-Acid Transaminase |
| ID | Term |
|---|---|
| D000637 | Transaminases |
| D019884 | Nitrogenous Group Transferases |
| D014166 | Transferases |
| D004798 | Enzymes |
| D045762 | Enzymes and Coenzymes |
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