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| Name | Class |
|---|---|
| University of Toronto | OTHER |
| Laval University | OTHER |
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The purpose of this study is to develop and test modified milk protein products to determine the effects of amino acids on food intake, satiety, insulin secretion and glucose control by insulin-independent action in healthy adults.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Water Control | Placebo Comparator | Skim milk products. Water and permeate control; 250mL serving. |
|
| Skim Milk | Active Comparator | Skim milk products. Skim milk (regular 80:20 protein ratio); 250mL serving. |
|
| High Protein Milk | Experimental | Skim milk products. High protein milk (regular 80:20 protein ratio); 250mL serving. |
|
| High Protein Milk (Modified Ratio) | Experimental | Skim milk products. High protein milk with modified protein ratio (40:60 ratio); 250 mL serving. |
|
| Skim Milk (Modified Ratio) | Experimental | Skim milk products. Skim milk with modified protein ratio (40:60 ratio); 250 mL serving. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Skim milk products | Other | Milk treatments will be served with 58g of breakfast cereal. |
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| Measure | Description | Time Frame |
|---|---|---|
| Postprandial Glycemia, as measured by capillary blood glucose (mmol/L) | 0-200 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Postprandial Satiety, as measured by paper 100-mm visual analogue scale (mm) | 0-200 minutes | |
| Food Intake at ad libitum lunch meal, as measured by weighed pizza consumption (g) | at 120 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Hormone and Amino Acid Analysis, as measured by biochemical assay (pmol/L and nmol/mL) | 0-200 minutes |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Amanda J Wright, Ph.D. | University of Guelph | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Guelph- Human Nutraceutical Research Unit | Guelph | Ontario | N1G2W1 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33024990 | Derived | Kung B, Turgeon SL, Vien S, Kubant R, El Khoury D, Wright AJ, Goff HD, Anderson GH. Role of Amino Acids in Blood Glucose Changes in Young Adults Consuming Cereal with Milks Varying in Casein and Whey Concentrations and Their Ratio. J Nutr. 2020 Dec 10;150(12):3103-3113. doi: 10.1093/jn/nxaa275. |
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| ID | Term |
|---|---|
| D006943 | Hyperglycemia |
| ID | Term |
|---|---|
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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