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| Name | Class |
|---|---|
| Rigshospitalet, Denmark | OTHER |
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To investigate gastrointestinal hormone secretions and nutrient absorption during the early meal phase we will recruit 12 healthy young men. They will be equipped with peripheral intravenous catheters for frequent blood sampling. Participants will be screened and acclimatised to the study situation on visit 1. On visit 2 and 3 participants will in random order ingest an oral glucose solution or a standardised liquid mixed meal over 2-3 min.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Oral glucose tolerance test | Experimental | Intervention: oral glucose tolerance test (75 gram glucose supplemented with 5g 3-OMG and 1g paracetamol) ingested over 2 min. |
|
| Liquid mixed meal test | Experimental | Intervention: Standardised liquid mixed meal (supplemented with 1g paracetamol) ingested over 2min |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Oral glucose tolerance test | Other | Oral glucose tolerance test will be carried out with a glucose solution made up of 75g glucose dissolved in 300mL. To the glucose solution will be added 5g 3-OMG and 1g paracetamol 5g 3-OMG |
| Measure | Description | Time Frame |
|---|---|---|
| Plasma GIP concentrations | Glucose-dependent insulinotropic polypeptide plasma concentrations | -40, -20, -18, -16, -14, -12, -10, -8, -6, -4, -2, 0, 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 30 min |
| Measure | Description | Time Frame |
|---|---|---|
| Plasma GLP-1 concentrations | Glucagon-like peptide-1 plasma concentrations | -40, -20, -18, -16, -14, -12, -10, -8, -6, -4, -2, 0, 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 30 min |
| Serum 3-OMG concentrations |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Simon Veedfald, MD | Contact | +45 41102595 | veedfald@sund.ku.dk | |
| Jens J Holst, DMSCI | Contact | jjholst@sund.ku.dk |
| Name | Affiliation | Role |
|---|---|---|
| Jens J Holst, DMSCI | Department of Biomedical Sciences | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Gastrointestinal Surgery, Righospitalet | Recruiting | Copenhagen | Capital | 2100 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34479362 | Derived | Veedfald S, Rehfeld JF, van Hall G, Svendsen LB, Holst JJ. Entero-Pancreatic Hormone Secretion, Gastric Emptying, and Glucose Absorption After Frequently Sampled Meal Tests. J Clin Endocrinol Metab. 2022 Jan 1;107(1):e188-e204. doi: 10.1210/clinem/dgab610. |
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| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| ID | Term |
|---|---|
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D005951 | Glucose Tolerance Test |
| ID | Term |
|---|---|
| D001774 | Blood Chemical Analysis |
| D019963 | Clinical Chemistry Tests |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
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12 healthy male individuals will each be studied on two occasions in random order.
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| Liquid mixed meal test | Other | A standardised liquid mixed meal test will be carried out using a standard liquid mixed meal (fresubin drink supplemented with 1g paracetamol). |
|
Serum 3-OMG concentrations (glucose absorption marker)
| -10, -2, 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 30 |
| Serum C-peptide and insulin concentrations | Glucagon-like peptide-1 plasma concentrations | -40, -20, -18, -16, -14, -12, -10, -8, -6, -4, -2, 0, 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 30 min |
| Plasma gastrin concentrations | Plasma gastrin concentrations | -40, -20, -18, -16, -14, -12, -10, -8, -6, -4, -2, 0, 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 30 min |
| Plasma CCK concentrations | Plasma cholecystokinin concentrations | -40, -20, -18, -16, -14, -12, -10, -8, -6, -4, -2, 0, 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 30 min |
| Plasma PP concentrations | Plasma pancreatic polypeptide concentrations | -40, -20, -18, -16, -14, -12, -10, -8, -6, -4, -2, 0, 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 30 min |
| Plasma NT concentrations | Plasma Neurotensin concentrations | -40, -20, -18, -16, -14, -12, -10, -8, -6, -4, -2, 0, 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 30 min |
| Plasma glucagon concentrations | Plasma glucagon concentrations | -40, -20, -18, -16, -14, -12, -10, -8, -6, -4, -2, 0, 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 30 min |
| Serum 3-OMG concentrations | Serum 3-OMG concentrations (glucose absorption marker) | -40, -20, -18, -16, -14, -12, -10, -8, -6, -4, -2, 0, 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 30 min |
| Plasma acetaminophen | Plasma acetaminophen (as a measure of gastric emptying) | -10, -2, 0, 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 30 min |
| Plasma amino acids | Plasma amino acids | -10, -2, 0, 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 30 min |
| Plasma bile acids | Plasma bile acids | -10, -2, 0, 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 30 min |
| D003933 | Diagnosis |
| D003940 | Diagnostic Techniques, Endocrine |
| D008919 | Investigative Techniques |