Studies of the Early Meal Phase in Healthy Individuals - Nutrient Absorption and Gastrointestinal Hormone Secretion

Studier af Den Tidlige Måltidsfase i Raske Individer

To investigate gastrointestinal hormone secretions and nutrient absorption during the early meal phase we will recruit 12 healthy young men. They will be equipped with peripheral intravenous catheters for frequent blood sampling. Participants will be screened and acclimatised to the study situation on visit 1. On visit 2 and 3 participants will in random order ingest an oral glucose solution or a standardised liquid mixed meal over 2-3 min.

Inclusion Criteria:

• Age between 18 and 40years
• Male
• Normal Haemoglobin concentration
• Informed consent

Exclusion Criteria:

• Diabetes mellitus
• Family history of diabetes mellitus
• intestinal disease (for example inflammatory bowel disease or malabsorption)
• Family history of inflammatory bowel disease
• Previous intestinal resection (except uncomplicated appendicectomy)
• Body mass index (BMI) > 25 kg/m2
• Tobacco use
• kidney disease (se-creatinine> 130 µM and/or albuminuria)
• liver disease (ALAT and/or ASAT >2 × above normal range)
• Heart disease
• Treatment with drugs
• History of constipation
• Conditions with delayed or accelerated gastric emptying
• Latex or other allergies
• Bleeding diathesis